Lipids

BP Lipid 212 is an amino ionizable lipid analogous to BP-25499. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C8 and C10 position relative to the amine nitrogen. The primary ester has lipid a long 11-carbons tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 213 is an amino lipid with ester bonds located at C10 and C8 position relative to nitrogen amine. The ethanolamine head can effectively enhance mRNA encapsulation while ester bonds improve tissue clearance. The primary lipid tail contains 11 carbons. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 214 is an inonizable amine lipid with two ester linkages at C10 position relative to amine. The primary C10 ester has a long 11 carbons lipid tail. The head of lipid is ethanolamine which can effectively encapsulate mRNA used in gene therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Boc-Gly-Gly is a peptide linker. The Boc group can be deprotected under mild acidic conditions to form the free amine.

DL-Thioctic acid contains a lipoic acid group and a terminal carboxylic acid group. The carboxylic acid groups can undergo sequential amide coupling reaction with amine-bearing biomolecules in the presence of EDC, HATU, and DCC to form stable amide bonds.

1-Bromoundecane is a chemical reagent featuring a bromide along a saturated C11 chain. Bromide is easily displaced by nucleophiles such as alcohols or amines. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

6-Bromo-1-hexanol posesses a terminal bromine and hydroxylic group. The bromine is a very good leaving group for nucleophilic substitution reactions. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

4-Amino-1-butanol posesses a terminal amine and hydroxylic group. Amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

2-Hexyldecanoic acid is a lipid with a carboxylic acid group and two non-polar tails. The carboxylic acid groups can undergo sequential amide coupling reactions with amine-bearing biomolecules in the presence of EDC, HATU and DCC to form stable amide bonds.