Lipids

LNP-0315 is a lipid nanoparticle (LNP) formulated with ALC-0315, DSPC, Cholesterol, and ALC-0159. LNP-0315 is formulated at optimal molar ratio for efficient delivery of mRNA-based vaccines.

LNP-0315 is a lipid nanoparticle (LNP) formulated with ALC-0315, DSPC, Cholesterol, and ALC-0159. LNP-0315 is formulated at optimal molar ratio for efficient delivery of mRNA-based vaccines.

Arachidonoyl LPA-d5 is a deuterated analog of 20:4 LPA labeled on the glycerol backbone. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion. May contain up to 15% of the 2-acyl isomer due to acyl transfer.

mPEG-DSPE 2000 is a derivative of phosphatidylethanolamine and is used to increase the circulation time of liposomes and lipid nanoparticles (LNPs) in vivo. The hydrophilic PEG chains decrease interactions with the reticular-endothelial system and increases the size of the particles both of which result in lowered clearance rate from the body.

306Oi10 is a biodegradable branched chain lipidoid developed for RNA delivery in lipid nanoparticles (LNPs). Interestingly the unbranched analog was 10-fold less effective in delivering luciferase mRNA in mice. The increased potency is thought to be due to increased cone-shaped structure and protonation at endosomal pH resulting in enhanced endosomal escape. 306Oi10 has been used to co-deliver three mRNAs (firefly luciferase mCherry and erythropoietin). The LNPs derived from 306Oi10 were not immunogenic or toxic to the liver. Incorporation of DOTAP into 306Oi10 LNPs resulted in increased targeting of mRNA to pancreatic β cells via intraperitoneal injection in mice.

DOTAP forms stable cationic liposomes in solution and can be used in the cell transfection of DNA RNA oligonucleotides anionic proteins and small peptides.

DOTMA forms stable cationic liposomes in solution and can be used in the cell transfection of DNA RNA oligonucleotides anionic proteins and small peptides. DOTMA increased by at least 1000-fold the activity of an antisense oligonucleotide (ISIS 1570) in human umbilical vein endothelial cells.

DODMA is an ionizable lipid used for preparation of lipid nanoparticles and liposomes for delivery of RNA and DNA.

9A1P9 is a multi-tail ionizable phospholipid which promotes membrane destabilization and cargo release enhancing mRNA delivery and gene editing. Lipid nanoparticles prepared with 9A1P9 exhibited 40- to 965-fold higher in vivo mRNA delivery efficacy compared to DOPE and DSPC.