Lipids

14:0 DAP, also known as 1,2-dimyristoyl-3-dimethylammonium-propane, is a cationic lipid that can be used to formulate lipid nanoparticles (LNPs). It also serves as a pH-sensitive transfection reagent.

DORI, N-(2-hydroxyethyl)-N,N-dimethyl-2,3-bis(oleoyloxy)propan-1-aminium bromide, is a cationic lipid with lower cytotoxicity and high transfection efficiency.

DOBAQ, N-(4-carboxybenzyl)-N,N-dimethyl-2,3-bis(oleoyloxy)propan-1-aminium, is a cationic lipid with a quaternary amine and unsaturated hydrocarbon chains. DOBAQ also serves as a pH-sensitive transfection reagent.

16:0 DAP, 1,2-dipalmitoyl-3-dimethylammonium-propane, is a cationic lipid that can be used to formulate lipid nanoparticles (LNPs). It also serves as a pH-sensitive transfection reagent.

8-bromooctyl 2-hexyldecanoate is an intermediate for the synthesis of lipid molecules.

Palmitic acid-PEG4-NHS ester is a saturated long-chain fatty acid with a 16-carbon backbone and a PEG linker connected to a terminal NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media.

6-(3-hydroxypropylamino)hexyl 2-hexyldecanoate is an ionizable lipid which can be used to make ALC-0315. The ethanolamine lipid head enhances encapsulation of mRNA. The lipid has an ester bond adjacent to C6 relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver.

bis(2-butyloctyl) 10-oxononadecanedioate is an ionizable lipid-like compound containing four hydrophobic tails bound by esters. It can be used to build lipids for mRNA encapsulation and delivery.

heptadecan-9-yl 10-bromodecanoate is an intermediate for the synthesis of lipid molecules.