Lipids

DOPE-PEG-Azide, MW 5,000 is a polydisperse PEG covalently attached to a phospholipid. The polymer is an amphiphilic molecule with hydrophobic fatty acid chains and hydrophilic PEG head which enables lipid bilayer or micelles formation in water. The phospholipid PEG can be used to prepare liposome or nanoparticles for targeted drug delivery and is reactive with alkyne to form a triazole ring. Reagent grade, for research use only.

DSPE-PEG-COOH, MW 2,000 is a PEG polymer with hydrophilic phosphate head and hydrophobic lipid tails. The polymer can self-assemble to form lipid bilayers in water. The phospholipid polyPEG can be used as a drug nanocarrier for administration of nutrients and therapeutic drugs, such as liposome in mRNA or DNA vaccines. The terminal carboxylic acid can react with primary amine groups to form a stable amide bond. The long PEG spacer increases reagent's solubility in aqueous media. Reagent grade, for research use only.

DSPE-PEG-COOH, MW 5,000 is a PEG polymer with hydrophilic phosphate head and hydrophobic lipid tails. The polymer can self-assemble to form lipid bilayer in water. The phospholipid polyPEG can be used as a drug nanocarrier for administration of nutrients and therapeutic drugs, such as liposome in mRNA or DNA vaccines. The terminal carboxylic acid can react with primary amine groups to form a stable amide bond. The long PEG spacer increases reagent's solubility in aqueous media. Reagent grade, for research use only.

DSPE-PEG-Azide, MW 600 is a polydisperse PEG covalently attached to a phospholipid. The polymer is an amphiphilic molecule with hydrophobic fatty acid chains and hydrophilic PEG head. The phospholipid PEG can be used to prepare liposome or nanoparticles for targeted drug delivery and the azide is reactive with alkynes to form triazole rings. Reagent grade, for research use only.

18-Methoxy-18-oxooctadecanoic acid is a long alkane linker with a terminal carboxylic acid group. The terminal carboxylic acid group can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. Reagent grade, for research use only.

5-((pentadecan-7-yloxy)carbonyl)pentanoic acid is a lipid building block with a terminal carboxylic acid group. The acid group can derivatize amine-containing molecules in the presence of activators such as EDC or HATU. Reagent grade, for research use only.

3-Hydroxy-2-(hydroxymethyl)propyl 6-bromohexanoate is a branched PEG linker with bromine and hydroxyl moieties. The alcohol groups can react to further derivatize the compound. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions. Reagent grade, for research use only.

DSPE-PEG13-NHS is a PEG linker containing DSPE and amine moieties. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG linker increases the water solubility of the overall compound allowing for the delivery of the drug. The amine group is reactive with NHS ester at pH 6.5-7.5 to form a covalent amide bond. Reagent grade, for research use only.

DSPE-PEG8-amido-DBCO is a PEG linker containing DSPE and DBCO moieties. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG linker increases the water solubility of the overall compound allowing for the delivery of the drug. The DBCO group can be used for copper-free Click Chemistry reactions. Reagent grade, for research use only.