Lipids

Palmitoleic acid is an unsaturated fatty acid that contains 16 carbon atoms and a double bond seven carbon atoms from the end of the chain. Reagent grade, for research use only.

FMOC-L-LYS[OCT-(OTBU)-GLU-(OTBU)-AEEA-AEEA]-OH is a useful research chemical used in the preparation of semaglutide. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3 4 5)P3. This analog of PI(4 5)P2 is labeled with the red fluorophore Cyanine 5 (Cy5)

NBD PtdIns(4 5)P2 C16 is an analog of PItdIns(4 5)P2 (PIP2) labeled with NBD on the sn-1 acyl chain. Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in several tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3 4 5)P3.

Cardiolipin is an important component in prokaryotic  and in eukaryotic inner mitochondrial membrane.1  In humans CL is made by cardiolipin synthase from phosphatidylglycerol and cytidinediphosphate-diacylglycerol. 2  Due to its four acyl chains and small head group CL can organize into domains which can be proton sinks fill cavities at protein interfaces stabilize protein oligomers and participate in high-curvature membrane regions.  Autoantibodies to CL have been found in patients with anti-phospholipid syndrome and lupus3.

Lipid A6 is an ionizable and biodegradable lipid that is used to formulate lipid nanoparticles (LNPs) for delivering RNA. Lipid A6 has similar structure as Dlin-MC3-DMA but with ester and alkyne bonds to improve its biodegradability and cell membrane fusion ability. Lipid A6 forms lipid-like nanoparticles together with cKK-E12 synergistically to facilitate robust mRNA delivery with improved tolerability. MC3 is the key delivery nanoparticle component of the first siRNA drug Onpattro.

Lipid 319 is an ionizable and biodegradable lipid. Lipid 319 nanoparticles have better delivery efficacy and biodegradability than DLin-MC3-DMA in the delivery of mRNA in vivo. MC3 is the key delivery nanoparticle component of the first siRNA drug Onpattro.

cKK-E12 is an ionizable lipomer that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA. The pKa is 6.5. Reagent grade, for research use only.

DSPE-PEG4-Maleimide is a PEG linker with a maleimide group and a hydrophilic phosphate head with hydrophobic lipid tails. The polymer can self-assemble to form lipid bilayer in water. The phospholipid polyPEG can be used as a drug nanocarrier for administration of nutrients and therapeutic drugs, such as liposome in mRNA or DNA vaccines. The maleimide group will react with a thiol group to form a covalent bond. Reagent grade, for research use only.