Lipids

Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion. May contain up to 15% of the 2-acyl isomer due to acyl transfer.

Palmitoyl dihydroxyacetone phosphate ammonium salt (Palmitoyl-DHAP) is an ether lipid implicated in cell membrane function cell signaling and is involved in lipid biosynthesis.Ether lipids have been implicated in cell membrane function and can act as signaling molecules; however their roles in cell physiology are still not completely understood. The key step for ether lipid biosynthesis is the conversion of acyldihydroxyacetone phosphate (acyl-DHAP) to alkyldihydroxyacetone phosphate (alkyl-DHAP) by the enzyme alkyldihydroxyacetone phosphate synthase (ADPS alternately referred to as AGPS). Recently elevated levels of ADPS have been found in human cancer cells and primary tumors which lead to increased levels of oncogenic signaling lipids.

Hexadecyl dihydroxyacetone phosphate ammonium salt (Hexadecyl-DHAP) is an ether lipid implicated in membrane function and is involved in lipid biosynthesis.Ether lipids have been implicated in cell membrane function and can act as signaling molecules; however their roles in cell physiology are still not completely understood. The key step for ether lipid biosynthesis is the conversion of acyldihydroxyacetone phosphate (acyl-DHAP) to alkyldihydroxyacetone phosphate (alkyl-DHAP) by the enzyme alkyldihydroxyacetone phosphate synthase (ADPS alternately referred to as AGPS). Recently elevated levels of ADPS have been found in human cancer cells and primary tumors which lead to increased levels of oncogenic signaling lipids.

9Z-Octadecenyl phosphate ammonium salt (ODP) is a fatty alcohol phosphate analog of oleoyl-LPA. It does not activate or inhibit Ca2+-mobilization in LPA1-3 expressing RH7777 cells. However it potentiates the agonist activity of oleoyl-LPA on LPA receptor expressing cells.G.G. Durgam et al. “Synthesis Structure-Activity Relationships and Biological Evaluation of Fatty Alcohol Phosphates as Lysophosphatidic Acid Receptor Ligands Activators of PPAR? and Inhibitors of Autotaxin” J. Med. Chem. 2005 48 4919-4930

1 2-Dilauroyl-sn-glycero-3-phosphocholine (DLPC) is the dilauroyl diester of phosphatidiylcholine one of the most common cell membrane lipids.Phosphatidylcholine (PC) is generally the most abundant lipid in animal cell membranes providing structural framework. PC is more common in the outer leaflet where it functions as part of the permeability barrier. PC is also the primary substrate of Phospholipase D enzymes which produce the signaling lipids - phosphatidic acid and lysophosphatidic acid.Publications Powered by Bioz See more details on Bioz

1 2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes.Phosphatidylcholine (PC) is generally the most abundant lipid in animal cell membranes providing structural framework. PC is more common in the outer leaflet where it functions as part of the permeability barrier. PC is also the primary substrate of Phospholipase D enzymes which produce the signaling lipids - phosphatidic acid and lysophosphatidic acid. Powered by Bioz See more details on Bioz

1 2-Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) is a phosphocholine with two palmitic acids on its head-group and is used in formulation of medicines.Phosphatidylcholine (PC) is generally the most abundant lipid in animal cell membranes providing structural framework. PC is more common in the outer leaflet where it functions as part of the permeability barrier. PC is also the primary substrate of Phospholipase D enzymes which produce the signaling lipids - phosphatidic acid and lysophosphatidic acid. Powered by Bioz See more details on Bioz

1-Margaroyl-2-oleoyl-sn-glycero-3-phosphocholine (MOPC 17:0/18:1 PC) is phosphocholine with heptadecanoyl and oleoyl acyl groups.Phosphatidylcholine (PC) is generally the most abundant lipid in animal cell membranes providing structural framework. PC is more common in the outer leaflet where it functions as part of the permeability barrier. PC is also the primary substrate of Phospholipase D enzymes which produce the signaling lipids – phosphatidic acid and lysophosphatidic acid.

1 2-Distearoyl-sn-glycero-3-phosphocholine (DSPC) is a phosphatidylcholine with stearoyl (octadecanoyl) acyl groups. It derives from an octadecanoic acid.Phosphatidylcholine (PC) is generally the most abundant lipid in animal cell membranes providing structural framework. PC is more common in the outer leaflet where it functions as part of the permeability barrier. PC is also the primary substrate of Phospholipase D enzymes which produce the signaling lipids - phosphatidic acid and lysophosphatidic acid.Storage: 4°C or belowKeywords: PC(18:0/18:0) DSMPC Distearoyl phosphatidylcholinePublications Powered by Bioz See more details on Bioz