Lipids

t-butyl-C18-D-Glu-OtBu-PEG2-amide-PEG2-azide is a PEG linker comprised of an octadecanedioic acid and a glutamic acid, which is also protected by a terminal t-butyl ester, with a terminal t-butyl ester and an azide. The t-butyl groups can be deprotected under acidic conditions. Glutamic acid is an α-amino acid that is used in the biosynthesis of proteins. The azide group can react with alkyne, BCN, and DBCO via Click Chemistry to yield a stable triazole linkage. Reagent grade, for research use only.

t-butyl-C18-D-Glu-OtBu-PEG2-amide-PEG2-amine is a PEG linker comprised of an octadecanedioic acid and a glutamic acid, which is also protected by a terminal t-butyl ester, with a terminal t-butyl ester and an amine. The t-butyl groups can be deprotected under acidic conditions. Glutamic acid is an α-amino acid that is used in the biosynthesis of proteins. The amine group is reactive with activated NHS esters, carbonyls (ketone, aldehyde), etc. Reagent grade, for research use only.

Heptyl 8-bromooctanoate is an ester compound that has a terminal bromine. Heptyl 8-bromooctanoate is formed by coupling 8-Bromooctanoic acid to Heptanol. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions. Reagent grade, for research use only.

Cholesteryl chloroformate is used in the preparation of hydrophobized chitosan oligosaccharide and can be used in the application as an efficient gene carrier. Cholesteryl chloroformate acts as an initiator in the polymerization of methyl methacrylate. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

98N12-5 is a novel multi-tail ionizable lipids that has been used for efficient in vivo siRNA–delivery to the liver.

BAMEAO16B is a lipid nanoparticle. BAMEAO16B integrated with disulfide bonds, can efficiently deliver Cas9 mRNA and sgRNA into cells while releasing RNA in response to the reductive intracellular environment for genome editing. BAMEAO16B can be used for the research of gene editing. This product is provided as a solution in methyl acetate.

7-(3-hydroxypropylamino)heptyl 2-hexyldecanoate has a terminal hydroxide group and can be useful for the building or modification of lipid nanoparticles. Reagent grade, for research use only.

BP Lipid 301 is an ionizable lipid analogue of ALC-0315 featuring a propanolamine head and two carbamate tails at the C6 position relative to the amine, one being an undecyl tail and the other being a branched C17. The ethanolamine head features an alcohol which may be used for further derivatization. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 302 is an ionizable lipid analogue of ALC-0315 featuring a butanolamine head and two carbamate tails at the C6 position relative to the amine, one being an undecyl tail and the other being a branched C17. The ethanolamine head features an alcohol which may be used for further derivatization. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.