Lipids

Ethyl 6-azidohexanoate comprises an ethyl ester and a terminal azide group with a 5-carbon linker. The azide can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions. Reagent grade, for research use only.

Amine-Tri(3-methoxypropanamide-PEG10-Propargyl) Methane HCl salt is reactive with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. Reagent grade, for research use only.

nonyl 7-bromoheptanoate can be useful for the preparation of lipid nanoparticles. Reagent grade, for research use only.

(6-(4-hydroxybutylamino)hexyl)carbamic undecyl has a terminal hydroxide group and can be useful for the building or modification of lipid nanoparticles. Reagent grade, for research use only.

ATX-001, also known as O-11280, is an ionizable lipid with a sulfur bond near the polar head and a pair of unsaturated tails. It is useful for the development of lipidoid nanoparticles for siRNA, mRNA, and vaccine delivery. Reagent grade, for research use only.

DODAC is a cationic lipid with a pair of unsaturated tails. This complex can serve as a well-defined intermediate in the preparation of DNA-lipid particles (DLPs) with many potential applications for delivery of polynucleotides in vitro and in vivo. Reagent grade, for research use only.

Propane-1,3-(PEG12-DBCO),2-alcohol is a PEG linker containing two DBCO moieties and a terminal primary hydroxyl group. The hydroxyl can react with a variety of functional groups and the hydrophilic PEG spacer arm can provide better solubility to labeled molecules. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only.

Carboxy-Amido-PEG4-Amine is a PEG reagent containing an amino (NH2) and a terminal carboxylic acid group. The hydrophilic PEG unit increases hydrophilicity. NH2 amine group is reactive with carboxylic acids in the presence of coupling reagent such as EDC, or directly with NHS esters, to form a stable amide bond. Reagent grade, for research purpose.

20-(Bromoacetamido-PEG4-ethylcarbamoyl)heptadecanoic acid is a PEG linker containing Bromoacetamido and carboxylic acid groups. The bromo is a good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. Reagent grade, for research purpose.