Cell Line

Please note this product may be subject to fees, we invite you to contact your local office. ADAR1 Activity Luciferase Reporter HEK293 Cell Line is a HEK293 cell line designed to monitor the activity of ADAR1 (adenosine deaminase acting on RNA) enzyme. These cells were engineered to express ADAR1 (NM_001111.5) and an ADAR1 reporter construct comprised of an ADAR1 hairpin target with a stop codon (UAG) susceptible to ADAR1-mediated editing to tryptophan (UUG), located upstream of a firefly luciferase reporter. This cell line has been validated by comparing reporter activation to ADAR1 Responsive Luciferase Reporter HEK293 Cell Line (#82238) and in response to treatment with ADAR1 siRNA. The ADAR1 reporter construct is comprised of an ADAR1 hairpin target with a stop codon (UAG) upstream of the sequence encoding luciferase. In the absence of ADAR1, luciferase is not transcribed, and the cells show no luciferase activity. In the presence of ADAR1 activity, adenine is converted into inosin

CRISPR-Ready ioGlutamatergic Neurons

CRISPR-Ready ioMicroglia

Please note this product may be subject to fees, we invite you to contact your local office. The Dual Epitope Anti-BCMA CAR-T Cells are generated via high-titer lentiviral transduction of human primary CD4⁺and CD8⁺ T cells <u>with the SIN Anti-BCMA CAR Lentivirus (VHH1/VHH2 ScFv-CD8-4-1BB-CD3ζ) (#78783)</u>. These ready-to use CAR (chimeric antigen receptor)-T cells express an anti-BCMA CAR consisting of a ScFv (single-chain variable fragment) that recognizes two BCMA epitopes (VHH1 and VHH2) linked to a CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains. These CAR-T cells have been validated by flow cytometry (to determine the CAR expression) and in co-culture cytotoxicity assays.

Please note this product may be subject to fees, we invite you to contact your local office. The Dual Epitope Anti-BCMA CAR-T Cells are generated via high-titer lentiviral transduction of human primary CD4⁺and CD8⁺ T cells <u>with the SIN Anti-BCMA CAR Lentivirus (VHH1/VHH2 ScFv-CD8-4-1BB-CD3ζ) (#78783)</u>. These ready-to use CAR (chimeric antigen receptor)-T cells express an anti-BCMA CAR consisting of a ScFv (single-chain variable fragment) that recognizes two BCMA epitopes (VHH1 and VHH2) linked to a CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains. These CAR-T cells have been validated by flow cytometry (to determine the CAR expression) and in co-culture cytotoxicity assays.

Please note this product may be subject to fees, we invite you to contact your local office. The Membrane-Bound TNFα CHO Cell Line is a clonal CHO cell line stably expressing human membrane-bound TNFα (tumor necrosis factor alpha) driven by an EF1a promoter. The cells were generated by transduction with Membrane-Bound TNFα (mTNFα) Lentivirus (#78955).

Please note this product may be subject to fees, we invite you to contact your local office. Androgen Luciferase Reporter 22RV1 Cell Line is a human 22Rv1 cell line with a stably integrated Firefly luciferase reporter under the control of an androgen response element. This cell line monitors the activity of the androgen receptor signaling pathway. This cell line has been validated in cellular assays involving the inhibition of 5α-Dihydrotestosterone (5-DHT)-induced reporter activation by AR (androgen receptor) antagonists such as Enzalutamide, Bicalutamide, Mifepristone and ARCC-4.

Please note this product may be subject to fees, we invite you to contact your local office. The HLA-C*08:02 K562 Cell Line is an engineered human lymphoblast K562 cell line expressing human HLA-C*08:02 driven by an EF1a promoter. This cell line was generated by transduction with HLA-C*08:02 Lentivirus (BPS Bioscience #78930). This cell line has been validated by flow cytometry and co-culture assays with Jurkat cells expressing KRAS G12D, in the presence of wild type and mutant KRAS peptides

Please note this product may be subject to fees, we invite you to contact your local office. MAGE-A4 CD8⁺ NFAT-Luciferase Reporter Jurkat Cell Line was generated from T Cell Receptor (TCR) Knockout NFAT Luciferase Reporter Jurkat Cell Line (BPS Bioscience #78556) by overexpression of human CD8 (NM_001768.6) and a MAGE-A4 (Melanoma-associated antigen 4)-directed TCR using lentiviral transduction (CD8a Lentivirus #78648 and MAGE-A4-Specific TCR Lentivirus #78935). This human MAGE-A4 TCR specifically recognizes an antigen corresponding to MAGE-A4 peptide, amino acids 230-239 (GVYDGREHTV).