Cell Line

Please note this product may be subject to fees, we invite you to contact your local office. The Anti-mesothelin CAR-T cells are produced by high-titer lentiviral transduction of human primary CD4+CD8+ T cells using the anti-Mesothelin CAR Lentivirus (Mesothelin ScFv-CD8-4-1BB-CD3ζ; BPS Bioscience #78703). These ready-to use CAR-T cells express an anti-Mesothelin CAR consisting of the scFv (Single chain fragment variable) of anti-Mesothelin (clone P4) linked to a 2^nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains (Figure 1). These CAR-T cells have been validated using flow cytometry (to determine the CAR expression) and co-culture cytotoxicity assays. <img style="display: block; margin-left: auto; margin-right: auto;" src="{{media url="wysiwyg/Imtx/78729.png"}}" alt="" width="433" height="114" /> Figure 1: Construct diagram showing components of the anti-Mesothelin CAR expressed in anti-Meso

Please note this product may be subject to fees, we invite you to contact your local office. The NK Cell Expansion Kit is suitable for the ex vivo culture and expansion of human natural killer (NK) cells. It contains engineered Growth-Arrested NK Feeder Cells and NK Cell Basal Medium. The Growth-Arrested NK Feeder Cells are K562 cells engineered to express membrane bound IL-21, and other components, to drive the robust activation and expansion of NK cells. The kit provides enough growth-arrested feeder cells for a starter population of 1 million purified NK cells or PBMC cells.

Please note that an MTA needs to be signed prior to purchase of this product, we kindly request that you contact your local office. This product is provided at this price to private organisations.

Please note that an MTA needs to be signed prior to purchase of this product, we kindly request that you contact your local office. This product is provided at this price to private organisations.

Please note that an MTA needs to be signed prior to purchase of this product, we kindly request that you contact your local office. This product is provided at this price to private organisations.

Please note that an MTA needs to be signed prior to purchase of this product, we kindly request that you contact your local office. This product is provided at this price to academic organisations (not for profit).

Please note that an MTA needs to be signed prior to purchase of this product, we kindly request that you contact your local office. This product is provided at this price to private organisations.

Please note that an MTA needs to be signed prior to purchase of this product, we kindly request that you contact your local office. This product is provided at this price to academic organisations (not for profit).

Please note that an MTA needs to be signed prior to purchase of this product, we kindly request that you contact your local office. This product is provided at this price to private organisations.