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Activators & Inhibitors

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    Results for Activators & Inhibitors ( 107979 )

      • 7-Chlorokynurenic acid sodium salt

        Ref: T10191
        Sizes: 2 mg, 1 mL * 10 mM (in DMSO)
        From: €50.00

        7-Chlorokynurenic acid sodium salt (Legacy Tebubio ref. 282T10191). 7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the NMDA receptor (IC50: 0.56 μM) and a potent inhibitor of the reuptake of glutamate into synaptic vesicles (Ki: 0.59 μM).

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      • 7-Chlorokynurenic acid

        Ref: T10191L
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €44.00

        7-Chlorokynurenic acid (Legacy Tebubio ref. 282T10191L). 7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.

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      • 7-O-Geranylscopoletin

        Ref: T10195
        Sizes: 5 mg, 1 mL * 10 mM (in DMSO)
        Price Enquiry

        7-O-Geranylscopoletin (Legacy Tebubio ref. 282T10195). 7-O-Geranylscopoletin is a natural coumarin from the root of Atalantia monophylla. Various parts of this plant have been used for folk medicine for several purposes such as the treatment of chronic rheumatism, antispasmodic, paralysis, hemiplegia, and stimulant.

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      • 7α-Hydroxy-4-cholesten-3-one

        Ref: T10196
        Sizes: 1 mg, 5 mg, 25 mg, 50 mg, 10 mg
        From: €329.00

        7α-Hydroxy-4-cholesten-3-one (Legacy Tebubio ref. 282T10196). 7α-Hydroxy-4-cholesten-3-one is an intermediate in bile acid synthesis from cholesterol, a PXR agonist, and a biomarker for bile acid loss and diseases related to defective bile acid biosynthesis. It is also the physiological substrate for [CYP8B1].

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      • 8,​9-​Epoxy-​3-​isobutyryloxy-​10-​(2-​methylbutanoyl)​thymo

        Ref: T10197
        Sizes: 1 mg, 5 mg, 1 mL * 10 mM (in DMSO)
        Price Enquiry

        8,​9-​Epoxy-​3-​isobutyryloxy-​10-​(2-​methylbutanoyl)​thymol (Legacy Tebubio ref. 282T10197). 8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol, a chemical component of essential oils from Telekia speciosa, exhibits significant antiproliferative activity against human cancer cell lines in vitro.

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      • 8-M-PDOT

        Ref: T10198
        Sizes: 1 mg, 5 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: €35.00

        8-M-PDOT (Legacy Tebubio ref. 282T10198). 8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors. 8-M-PDOT exhibits anxiolytic activity and can be used to study MT2-induced neuropathic pain.

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      • GNF-PF-3777

        Ref: T10199
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg
        From: €35.00

        GNF-PF-3777 (Legacy Tebubio ref. 282T10199). GNF-PF-3777 (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2) with a Ki of 0.97 μM.

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      • Doxorubicin hydrochloride

        Ref: T1020
        Sizes: 1 g, 25 mg, 100 mg, 50 mg, 500 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: €39.00

        Doxorubicin hydrochloride (Legacy Tebubio ref. 282T1020). Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitumor activity. Doxorubicin hydrochloride reduces the phosphorylation of AMPK and its downstream target protein acetyl coenzyme A carboxylase, and induces apoptosis and autophagy.

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      • 9-Hydroxyellipticine hydrochloride

        Ref: T10200
        Sizes: 1 mg
        From: €125.00

        9-Hydroxyellipticine hydrochloride (Legacy Tebubio ref. 282T10200). 9-Hydroxyellipticine hydrochloride is an inhibitor of Topo II and RyR, exhibiting antitumor, antioxidant, and catecholamine-releasing activities. It inhibits Hela S-3 and 293T cells with IC50s of 1.6 μM and 1.2 μM, respectively.

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