Results for Click Chemistry ( 905 )
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Val-Cit is a cleavable ADC linker used in antibody drug conjugate. The Val-Cit linker was designed to be cleaved by cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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t-butyl-octadecanedioate-NHS ester has a t-butyl ester group and an NHS ester moiety. The t-butyl group can be deprotected under acidic conditions. NHS ester can react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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6-(tert-Butoxy)-6-oxohexanoic NHS ester has a t-butyl ester group and an NHS ester moiety. The t-butyl group can be deprotected under acidic conditions. NHS ester can react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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10-(tert-Butoxy)-10-oxodecanoic NHS ester has a t-butyl ester group and an NHS ester moiety. The t-butyl group can be deprotected under acidic conditions. NHS ester can react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide ligated to an MMAE payload. Primary amines readily form amides with carboxylic acids in the presence of activator reagents such as HATU or EDC, while the Val-Cit-PAB motif is an enzyme-cleavable linker. This linker efficiently releases the toxin, MMAE, to target cells to cause cellular apoptosis.
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Azido-PEG4-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains an azido-PEG4 spacer, a protease-sensitive Val-Cit dipeptide, a PABC linker and a MMAE payload.Azido enable click chemistry with alkyne-bearing moiety Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.