Click Chemistry

TBTA was introduced shortly after the copper-catalyzed azide-alkyne cycloaddition reaction was discovered to mitigate thermodynamic instability of Cu(I) in aerobic media. TBTA is a water-insoluble ligand and must be first dissolved in DMSO or DMF. J Am Chem Soc., 143 (18), 6787-6791. T. R. Chan, R. Hilgraf, K. B. Sharpless, V. V. Fokin, Org. Lett. 2004, 6, 2853. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BTTES is a a next-generation, water-soluble ligand for the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) that accelerates reaction rates and suppresses cell cytotoxicity. The biocompatibility and fast kinetics of BTTES are advancements from water-insoluble TBTA and are desirable for bioconjugation in diverse chemical biology experiments. Angew. Chem. Int. Ed., 50: 8051-8056(2011) J. Am. Chem. Soc. 2010, 132, 47, 16893–16899(2010) Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BTTAA is a next-generation, water-soluble ligand for the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) that dramatically accelerates reaction rates and suppresses cell cytotoxicity. The biocompatibility and fast kinetics of BTTAA are advancements from water-insoluble TBTA and are desirable for bio conjugation in diverse chemical biology experiments. Angew. Chem. Int. Ed., 51: 5852-5856(2012) Nature Communications, 5, 4981 (2014) Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

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MMAF-PEG4-amine TFA salt is a PEG linker consisting of an MMAF warhead linked to a primary amine. The amine group can be linked to a number of different structures such as carboxylic acids, aldehydes, ketones, Michael acceptors, and heterocycles. The MMAF warhead is a toxin that is delivered to cells to cause apoptosis.

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THPTA is a water-soluble, very effective ligand for Cu(I)-catalyzed Alkyne-Azide click chemistry reactions (CuAAC). It serves a dual purpose: 1) Acceleration of the CuAAC reaction by maintaining the Cu(I) oxidation state of copper sources and 2) Protection of biomolecules from oxidative damage during the labeling reaction. THPTA is a superior alternative to water-insoluble TBTA. a) J. Am. Chem. Soc. 2011, 133, 17993. b) Bioconjugate Chem. 2010, 21, 1912. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

CL2A-SN38 is a SN38 derivative with a Mal-PEG attached peptide linker, it can easily react with antibody to form an antibody-drug conjugate (ADC). SN-38 is a potent DNA Topoisomerase I inhibitor. CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A linker is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

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