Click Chemistry

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PLGA(5k)-PEG(5k)-DBCO is a micelle-forming polymer with hydrophobic poly(lactide-co-glycolide) (PLGA) block chemically connected to a hydrophilic PEG block. The DBCO is reactive with azide via copper-free click chemistry to form a stable triazole bond. The PLGA core can be used to encapsulate hydrophobic drugs while the PEG can form a tight shell around the core to minimize drug degradation. The polyester PLGA is biodegradable via hydrolysis on the ester bonds. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

PLGA(10k)-PEG(2k)-DBCO is an cyclooctyne terminated block copolymer with hydrophobic poly(lactide-co-glycolide) (PLGA) and hydrophilic PEG blocks. The DBCO can react with azide readily (Cu-free) to form a covalent triazole bond. The biodegradable polymer can be used to prepare drug-loaded nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

PLGA(10k)-PEG(5k)-DBCO is an amphiphilic block copolymer with terminal DBCO moiety for click chemistry with azido molecule via SPAAC. The polymer can form micelles in water with core and shell made of poly(lactide-co-glycolide) (PLGA) and PEG, respectively. It can be used to encapsulate hydrophobic drugs. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

PLGA(20k)-PEG(2k)-DBCO is an azide reactive (Cu free) block copolymer which is biodegradable and amphiphilic. Upon dispersion in water, the self-assemble polymer forms micelles where the poly(lactide-co-glycolide) (PLGA) being shielded from water as core and the PEG block facing the water as shell. The core regions can serve as reservoirs for hydrophobic drugs. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

PLGA(20k)-PEG(5k)-DBCO is a linear homofunctional amphiphilic block copolymer. The polymer can self-assemble in water to form micelles with poly(lactide-co-glycolide) (PLGA) and PEG as core and shell, respectively. The polymer is reactive with azide via Cu free click chemistry to form a stable triazole linkage. This class of polymer is commonly used to prepare nanoparticles for drug delivery applicaiton. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

PLGA(30k)-PEG(2k)-DBCO is a diblock amphiphile polymer which forms micelles upon dispersion in water. The polymeric micelles consists of hydrophobic core-forming block poly(lactide-co-glycolide) (PLGA) and hydrophilic shell-forming PEG block. It can be used to encapsulate drugs for nanomedicine/drug delivery. The polyester PLGA is biodegradable via hydrolysis on the ester bonds. The DBCO moiety can react with azide molecule to form a stable triazole linkage via Strain Promoted Azided-Alkyne Cycloaddition (SPAAC). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

PLGA(30k)-PEG(5k)-DBCO can self-assemble in water to form polymeric micelles/nanoparticles. They consists of hydrophobic core-forming block poly(lactide-co-glycolide) (PLGA) and hydrophilic shell-forming PEG block. This biodegradable polymer can be used to encapsulate drugs in nanomedicine or drug delivery system. The cyclooctyne (DBCO) end-group is reactive with azido moiety via copper-free click chemistry. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

PLGA(40k)-PEG(2k)-DBCO is a self-assembling polymer with poly(lactide-co-glycolide) (PLGA) as hydrophobic block and PEG as hydrophilic segment. In water, the polymer forms micelles with PLGA as core and PEG as shell. The core regions can serve as reservoirs for hydrophobic drugs while the shell protects the core from enzymatic/hydrolysis degradation. The terminal DBCO is reactive with azido molecule via triazole linkage formation. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.