Click Chemistry

PLGA(40k)-PEG(5k)-DBCO is a polymer with both hydrophobic (poly(lactide-co-glycolide)/PLGA) and hydrophilic (PEG) blocks. The self-assembly of the polymer in water occurs with PLGA being shielded at the core by PEG shell. The hydrophobic core can be used to encapsulate lipophilic drugs while the PEG shell offers protection against (enzymatic/hydrolysis) degradation in drug delivery/nanomedicine. The DBCO is reactive with azide via copper-free click chemistry to form a stable triazole bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Nutlin-3 is an inhibitor of the MDM2-p53 interaction by occuping the binding site of p53 in MDM2 and consequently prevent MDM2 binding to p53 leading to the disruption of the autoregulator feedback loop and the fostering of the p53 tumor suppressor network. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

IBT6A is a Btk kinase inhibitor. This compound is a precurser for the manufacture of ibrutinib. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

MC-Val-Cit-PAB-MMAF is a cleavable ADC linker featuring a maleimide, a Val-Cit dipeptide, a PAB group, and an MMAF toxin. Maleimide is a thiol-specific covalent linker which is used to label cysteine residues in proteins while the Val-Cit dipeptide is a protease-cleavable motif which releases the MMAF warhead into cells via an elimination mechanism within the PAB structure.

N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodo-quinazolin-4-amine is a quinazoline derivative that has also been used in the design, synthesis and biological evaluation of quinazoline-phosphoramidate mustard conjugates as anticancer drugs. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

l-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-lHpyrazolo [3,4-d]pyrimidin-l-yl]-l-piperidinyl]-2-propyn-l-one, is a derivative of the first-in-class covalent BTK inhibitor ibrutinib. Ibrutinib inhibits B-cell proliferation and survival by irreversibly binding the protein Bruton's tyrosine kinase (BTK). B cell cancers are directly affected by this since the B-cell receptor pathway is often aberrantly active. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

4-(4-(4-(3-fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)phenol, is a derivative of the quinazoline containing drug Lapatinib. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

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