Click Chemistry

Mal-Val-Ala-PAB-PNP is a cleavable ADC linker. The Val-Ala linkers can be cleaved by Cathepsin B. Maleimide (Mal) group is reactive toward thiol groups. PNP is a good leaving group. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DBCO-PEG4-Val-Ala-PAB is a cleavable ADC linker. The Val-Ala linkers can be cleaved by Cathepsin B. The DBCO groups is commonly used for Click Chemistry reactions. PEG space improve compound's aqueous solubility. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DBCO-PEG4-Val-Ala-PAB-PNP is an ADC linker featuring a DBCO group, a hydrophilic PEG spacer, a Val-Ala dipeptide, a PAB group, and a PNP carbonate. DBCO is a click chemistry handle used to efficiently react with azides on target molecules, while the PNP carbonate is used to react with amines to ligate this linker with a payload to be delivered to cells. The Val-Ala dipeptide is subject to proteolysis within the cell, allowing for the PAB group to cause release the payload to the cytoplasm.

tert-butyl 7-hydroxyheptanoate is a linker with a hydroxyl group and a t-butyl ester. The hydroxyl group allows for further derivatization or replacement with many other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

tert-butyl 6-hydroxyhexanoate is a linker with a hydroxyl group and a t-butyl ester. The hydroxyl group allows for further derivatization or replacement with many other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fluorescein Biotin Azide is a trifunctional PEG linker containing an azide, a biotin group, and a fluorescein dye. The azide is a click chemistry handle which may be used to link with terminal alkynes or strained cyclooctynes like DBCO or BCN, while the biotin group is useful for affinity-based applications such as pull-down assays or for ligating with streptavidin proteins. Finally, the fluorescein is a near-UV/Vis spectrum dye that can be used for in vivo fluorescence assays.

Cy5 Azide NHS Ester is a fluorescent probe with terminal NHS ester and azide groups. The Cy5 fluorescent molecule is water-soluble, pH-insensitive from pH 4 to pH 10, far-red-fluorescent probe that is excitated at 633 nm and 647 nm. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage and as an azide-copper complex, the reaction works well under diluted conditions. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Coumarin Azide Plus is a fluroescent agent with a terminal azide group. The fluroescent compound has a max absorption at 340 nm and emission at 440 nm. The Coumarin Azide Plus was designed with a copper-chelating system within its structure enabling the formation of strong, active copper complexes that act as both reactant and catalyst in the CuAAC reaction. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Pyrene Azide Plus is a fluroescent agent with a terminal azide group. The Pyrene Azide Plus was designed with a copper-chelating system within its structure enabling the formation of strong, active copper complexes that act as both reactant and catalyst in the CuAAC reaction. The fluroescent compound has a max absorption at 403 nm and emission at 453 nm. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.