Click Chemistry

Val-Ala-PAB-OH is a cleavable ADC linker with a terminal hydroxyl group. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

endo-BCN-Val-cit-PAB-MMAE is a synthetic antibody drug conjugate coupled to an BCN group. It contains a a protease-sensitive Val-Cit dipeptide, and a MMAE payload. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. The BCN group can react with azide -tagged compound or biomolecules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DBCO-PEG4-MMAF is an antitubulin agent with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain allows for increased water solubility. MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DBCO-Val-Cit-PAB-MMAE is an ADC linker featuring a DBCO group, a Val-Cit dipeptide, a PAB motif, and an MMAE warhead. The DBCO group is a click chemistry handle which readily reacts with azide groups on a target molecule to form stable triazole linkages, while the Val-Cit dipeptide is a protease-cleavable motif which releases the MMAE warhead into cells via an elimination mechanism within the PAB structure.

BP Fluor 647 Alkyne is a bright green-fluorescent dye optimal for use with the 633, 650 nm Argon laser. The alkyne group can react with azides via copper catalyzed Click Chemistry reactions. The dye is water soluble and pH-insensitive from pH 4 to pH 10. The dye has 4 sulfonate groups make it high water soluble and less aggregation in the aqueous solution. BP Fluor 647 is used for protein and antibody labeling, or nucleic acid applications with high labeling density. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-DBCO-N-bis(PEG2-amide-PEG4-Val-cit-PAB-MMAE) is a precursor of antibody drug conjugate. It contains a DBCO group and two protease-sensitive Val-Cit dipeptide with MMAE payloads. DBCO group is a highly reactive cycloalkyne which is commonly used for copper-free Click Chemistry reactions. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

16-Aminohexadecanoic acid is an alkane chain with terminal carboxlic acid and amine groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

15-Aminopentadecanoic Acid can be used as a PROTAC linker in the synthesis of PROTACs. 15-Aminopentadecanoic Acid is an alkane chain with terminal carboxlic acid and amine groups. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

12-Aminododecanoic acid is an alkane chain with terminal carboxlic acid and amine groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.