Click Chemistry

tert-Butyl (7-aminoheptyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

tert-Butyl (5-aminopentyl)carbamate can be used as a PROTAC linker in the synthesis of PROTACs. tert-Butyl (5-aminopentyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Benzyl (6-oxohexyl)carbamate is a PEG linker containing an aldehyde group and a benzyl (Cbz) protecting group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The aldehyde can be used in PEGylation through its reaction with hydrazine or hydrazide forming a hydrolytic acyl hydrozone linkage. The benzyl protecting group can be removed via hydrogenolysis to form a free amine. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Benzyl (5-hydroxypentyl)carbamate is a linker capable of repairing damaged DNA by binding to the 5'-hydroxyl group on the sugar backbone. It can also bind to DNA ligands and can inhibit cell proliferation in resistant cell lines. However, benzyl (5-hydroxypentyl)carbamate is toxic to cells and can also cause DNA damage and strand breakage.

8-Nonynoicacid is a fatty acid that belongs to the group of octynoic acids. It exhibits antibacterial activity against gram-positive bacteria by binding to bacterial fatty acids. 8-Nonynoicacid also inhibits growth of gram-negative bacteria by inhibiting the synthesis of fatty acids. It is also capable of inhibiting growth of both aerobic and anaerobic bacteria in biochemical assays.

Hept-6-yn-1-yl 4-methylbenzenesulfonate is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

8-Bromooct-1-yne is a six carbon reagent containing an alkyne group and a bromide group. The alkyne group canreacts with azide-bearing compounds or biomolecules in Click Chemistry reactions under the catalyzation of copper. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2,5-Dioxopyrrolidin-1-yl hept-6-ynoate is an amine reactive four carbon reagent that can be used for derivatizing peptides, antibodies, amine coated surfaces etc. The alkyne group reacts with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

5-((tert-Butoxycarbonyl)amino)pentyl 4-methylbenzenesulfonate is a PEG linker containing a Boc protected amine and a tosyl group. The protected amine can be deprotected under mild acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.