Results for Click Chemistry ( 905 )
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Fmoc-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate containing a cleavable Val-Cit peptide, a PABC linker and a MMAE payload. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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N-Boc-Biocytin is a biotin PEG linker containing a carboxylic group and Boc-protected amine. Reaction of carboxylic with primary amino (-NH2) forms stable, irreversible amide bonds. The Boc group can be deprotected under acidic condition to obtain the free amine which can be used for further conjugations. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Biocytin is a biotin-lysine complex which can be used as an intracellular marker. Primary amine can be crosslinked to proteins or molecular surfaces using EDC. Biotinylated Lysine can be used as a quenching reagent in biotin assay methods. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Azido-PEG4-Ala-Ala-Asn(Trt)-PAB is a unique peptide cleavable ADC linker for antibody-drug-conjugation, Azido group is very reactive toward DBCO, BCN or other Alkyne groups, called click chemistry. The trt protecting group can be removed under acidic conditions. The hydrophilic PEG linker increases the water solubility of the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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MC-Val-Cit-PAB-PNP is a cleavable ADC linker which contains a maleimide, a valine-citrulline (Val-Cit dipeptide, and a para-nitrophenyl (PNP) group. Maleimide is a thiol-specific covalent linker which is used to label cysteine residues in proteins while the PNP carbonate acts as a highly activated leaving group which may be used to react with amines. Val-Cit linkers are cleaved by Cathepsin B.
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Sulfo-Cy3-Tetrazine is water soluble cyanine dye containing tetrazine moiety for the coupling with trans-cyclooctenes, which is an inverse electron demand [4+2] cycloaddition that takes place between tetrazine and trans-cyclooctene or other strained olefin. This fluorophore is bright and very well visible with naked eye. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.