Click Chemistry

Azido-PEG5-Ala-Ala-Asn-PAB PAB is a unique peptide cleavable ADC linker for antibody-drug-conjugation, Azido group is very reactive toward DBCO, BCN or other Alkyne groups, called click chemistry. PEG spacer increases the aqueous solubility. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Active-Mono-Sulfone-PEG8-acid is a PEG linker with a sulfone and acid end group. The sulfone group can be conjugated with thiol groups of proteins. The terminal carboxylic acid can react with primary amines in the presence of activators such as EDC and HATU to from stable amide bonds. The hydrophilic PEG chain increases the water solubility of the compound in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

diSulfo-Cy3 azide is a water-soluble dye containing an alkyne group, which enables Click Chemistry. Absorbance and emission of the dye are identical to Cy3 fluorophore. The reagent is designed for the labeling of proteins, and even intact biological objects in water phase. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

diSulfo-Cy3 azide is a water-soluble dye containing an azide group, which enables Click Chemistry. Absorbance and emission of the dye are identical to Cy3 fluorophore. The reagent is designed for the labeling of sensitive molecules such as proteins, and even intact biological objects in water phase. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

diSulfo-Cy5 Azide is a water-soluble dye containing an azide group, which enables Click Chemistry. Absorbance and emission of the dye are identical to Cy5 fluorophore. The reagent is designed for the labeling of sensitive molecules such as proteins, and even intact biological objects in the water phase. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Boc-Gly-Gly-N-[4-(hydroxymethyl)phenyl] Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

MS436, through a set of water-mediated interactions, exhibits low nanomolar affinity (estimated Ki of 30-50 nM) with preference for the first bromodomain over the second. MS436 effectively blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC50 values are 3.8 and 4.9 μM, respectively). MS436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Apabetalone (RVX-208) is an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Apabetalone has C50s are 87±10 μM and 0.51±0.041 μM for BD1 and BD2, respectively. Apabetalone binds to the acetyl-lysine binding pocket in a peptide-competitive way, which accounts for its pharmacological activity. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BI 2536 is a potent, ATP-competitive, well tolerated and effects Polo-like kinases (Plks) as well as a pan-BET (bromodomain and extra-terminal motif) family inhibitor. BI 2536 has an IC50s of 0.83 and 25 nM with PLK1 and BRD4 inhibitor, respectively. BI 2536 also blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. BI-2536 suppresses IFNB (encoding IFN-β) gene transcription. It also shows good blood-brain barrier permeability and causes mitotic arrest in glioblastoma-derived neural stem cells but not normal neural stem cells. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.