Click Chemistry

Ethyl 6-azidohexanoate is comprised of an ethyl ester and a terminal azide group with a 5-carbon linker. The azide can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions. Reagent grade, for research use only.

tert-Butyl N-(4-azidobutyl)carbamate is N-Boc protected crosslinker. The compound can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine. Reagent grade, for research use only.

Fmoc-Lys(MMt)-OH is a cyclic peptide that is synthesized using a liquid chromatograph. Fmoc-Lys(MMt)-OH has been found to be efficient in the industrial production of peptides with an amino acid sequence. Reagent grade, for research use only.

Fmoc-Lys(biotin)-OH is a biotinylation reagent with a terminal Fmoc group. The terminal biotinylation can react with amine molecules in the presence of activator EDC or HATU. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. Reagent grade, for research use only.

Fmoc-Lys(biotinyl-e-aminocaproyl)-OH is a biotinylation reagent with a terminal Fmoc group. The terminal biotinylation can react with amine molecules in the presence of activator EDC or HATU. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. Reagent grade, for research use only.

DM1-MCC-PEG4-DBCO is a drug-Linker Conjugates for ADC with a DM1 drug and a terminal DBCO group. DM1 can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

Azide-PEG8-Val-Cit-Doxorubicin is a precursor of antibody drug conjugate. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Doxorubicin is an anthracycline antibiotic with antineoplastic activity Reagent grade, for research purpose.

BP Fluor 647-PEG4-TCO is a water-soluble, pH-insensitive from pH 4 to pH 10 bright, far-red fluorescent probe with excitation ideally suited for the 633 nm or 647 nm laser lines. A significant advantage to using long wavelength dyes such as Cy5 or BP Fluor 647 dye over other fluorophores is the low autofluorescence of biological specimens in this region of the spectrum. BP Fluor 647 DBCO is a bright, far-red fluorescent, probe routinely used for imaging of azide-containing biomolecules without the need for copper catalyst. TCO reagent is highly reactive with tetrazine in an inverse electron demand Diels Alder (IEDDA) reaction followed by a retro-DA reaction. Reagent grade, for research purpose.

DBCO-PEG-amine TFA salt, MW 5,000 is a polyPEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound. Reagent grade, for research use only.