Click Chemistry

Tubastatin A is a potent HDAC6 inhibitor and demonstrates over 1,000-fold selectivity against most other HDAC isoforms, except HDAC8. Tubastatin A has also been shown to be an inhibitor of polymerase chain reaction (PCR). Tubastatin A binds to a specific site on the mitochondrial membrane potential, which is important for DNA replication. Reagent grade, for research purpose.

Voruciclib is a small-molecule pan-inhibitor of cyclin-dependent kinases. Voruciclib inhibits the proliferation of cancer cells by inducing apoptosis by inhibiting the expression and activity of the MCL-1 protein, which regulates cell death pathways. Reagent grade, for research purpose.

Chidamide is a nonsteroidal anti-inflammatory drug that inhibits the activity of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Chidamide has been shown to inhibit the growth of cancer cells, including lymphoma and leukemia. Chidamide's anti-cancer effects are mediated through inhibition of histone deacetylase enzymes and induction of apoptosis. Compared to some other benzamide type HDAC inhibitors, chidamide is more stable, more resistant to degradation and has a longer half-life. Reagent grade, for research purpose.

D-Desthiobiotin is a chemical reagent that is used for affinity-based applications such as pull-down assays or for ligating with streptavidin proteins while maleimide is a covalent linker that quickly reacts with thiol groups on proteins molecules. Desthiobiotin is a sulfur-free analogue of biotin which binds streptavidin with slightly less strength than biotin, which provides it with a soft-release characteristic that is useful for in pull-down assays by minimizing co-elution with endogenous biotinylated molecules.

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mPEG4-Val-Ala-PAB is an ADC linker featuring a hydrophilic PEG spacer, a Val-Ala dipeptide, and a p-aminobenzyl (PAB) group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Val-Ala dipeptide is cleaved by proteases to release a given drug payload via an elimination mechanism within the PAB group.

mPEG4-Val-Ala-PAB-PNP is an ADC linker featuring a hydrophilic PEG spacer, a Val-Ala dipeptide, and a p-aminobenzyl (PAB) group a PAB group, and a PNP carbonate. The PNP carbonate is highly activated towards attack from amines to form carbamate structures with an amine group on a target molecule. The Val-Ala dipeptide is cleaved by proteases to release a given drug payload via an elimination mechanism within the PAB group.

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