Click Chemistry

MC-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains a thio reactive maleimidocaproyl (MC) group, a protease-sensitive Val-Cit dipeptide, a PABC linker and a MMAE payload. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DBCO-PEG4-Val-Cit-PAB-MMAE is an ADC linker featuring a DBCO group, a hydrophilic PEG spacer, a Val-Cit dipeptide, a PAB motif, and an MMAE warhead. The DBCO group is a click chemistry handle which readily reacts with azide groups on a target molecule to form stable triazole linkages, while the Val-Cit dipeptide is a protease-cleavable motif which releases the MMAE warhead into cells via an elimination mechanism within the PAB structure.