Click Chemistry

BCN-PEG4-Glu-Gly-Cit-PAB-MMAE is a precursor of antibody drug conjugates (ADCs) containing a cleavable Glu-Gly-Cit (EGCit) peptide and a click-reactive BCN which can conjugate with an azide-containing moiety or monoclonal antibody (mAb). This peptide demonstrates exceptional durability in the bloodstream, remaining resistant to degradation and neutrophil protease cleavage, all while discreetly and tracelessly releasing payloads inside cells.

DBCO-PEG4-Glu-Gly-Cit-PAB-MMAE is a precursor for an antibody-drug conjugate (ADC) with a cleavable Glu-Gly-Cit (EGCit) peptide and a click-reactive DBCO for attaching to azide-containing compounds or anitbodies. It exhibits robust stability, resisting degradation and neutrophil protease cleavage while delivering payloads within cells discreetly and tracelessly.

Mal-Amide-PEG4-Glu-Gly-Cit-PAB-MMAE is comprised of a cathepsin-cleavable Glu-Gly-Cit (EGCit) peptide, a PABC linker, MMAE payload, and a maleimide group reactive toward thiol groups. This compound shows strong stability in the bloodstream and discreet, traceless intracellular payload release.

Azido-PEG4-Glu-Gly-Cit-PAB-MMAE possesses a cathepsin-cleavable Glu-Gly-Cit (EGCit) tripeptide, an azido-PEG4 spacer, a PABC linker, and a MMAE payload. Azido enables click chemistry with alkyne-bearing moieties. The peptide exhibits remarkable stability in the blood, resisting degradation and immune attacks, while enabling subtle and untraceable payload release within cells.

Boc-Glu(OtBu)-Gly-Cit, derived from Gly-Cit, is a tripeptide containing a Glu-Gly-Cit (EGCit) tripeptide and a Boc protecting group. This peptide maintains exceptional stability in the bloodstream, fending off degradation and immune assaults, all the while facilitating inconspicuous and untraceable payload delivery inside cells.

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3-Azido-7-hydroxycoumarin has the special property to become fluorescent only when it is click ligated. The formed triazole expands the electron system of the dye and enables fluorescence. Therefore, there is no background signal of the click unligated leftover dye. This dye is a valuable tool for nucleic acid labeling.

3-Azido-7-hydroxycoumarin has the special property to become fluorescent only when it is click ligated. The formed triazole expands the electron system of the dye and enables fluorescence. Therefore, there is no background signal of the click unligated leftover dye. This dye is a valuable tool for nucleic acid labeling.

Copper bromide (CuBr) is a source of a click-active copper species. In organic solvents it works optimal with TBTA as a ligand. Our CuBr is of high purity and we take especially care for its stability. In this state it is one of the most effective catalyst for click reactions. After solubilizing it is necessary to use it right away to avoid fast degradation (< 30 min).