Results for Click Chemistry ( 905 )
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3-Azidopropionic Acid contains an azide moiety and carboxylic acid group. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkyne groups. The terminal carboxylic acid group can react with primary amine groups in the presence of activators such as EDC or HATU to form stable amide bonds. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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BDP 630/650 azide is a BDP linker which can be read at the same channel as Cyanine5. It is a photostable compound and is commonly used for fluorescence polarization assays. The addition of the azide allows for it to be used in copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; it is a synthetic analog of dolastatin 10. Auristatin E is a highly potent antimitotic agent. Auristatin E inhibits tubulin polymerization(1). Auristatin E-antibody cunjugates have proven to be successful anticancer agents.(2)<br/>Ref. 1. Pettit et al. Anticancer Drug Des. 1995 10:529.<br/>Ref. 2. Doronina et al. Nature Biotechnol. 2003 21:778. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Ansamitocin P-3 (AP-3) is an active and potent anti-tumor maytansinoid, which is produced by Actinosynnema spp. Ansamitocin P-3 showed potent cytotoxicity against the human solid tumor cell lines A-549, HT-29. Ansamitocin P-3 is a useful material to make anticancer drug mertansine and emtansine. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Maytansine is a potent microtubule-targeted compound that inhibits proliferation of cells at mitosis. Antibody-maytansinoid conjugates consisting of maytansinoids (DM1 and DM4) attached to tumor-specific antibodies have shown promising clinical results The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their association with tubulin or microtubules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Mertansine, also called DM1 is a thiol-containing maytansinoid for therapeutic purposes. It can be attached to a monoclonal antibody through reaction of the thiol group with a maleimide linker to create an antibody-drug conjugate (ADC). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.