PEG

DSPE-PEG4-Maleimide is a PEG linker with a maleimide group and a hydrophilic phosphate head with hydrophobic lipid tails. The polymer can self-assemble to form lipid bilayer in water. The phospholipid polyPEG can be used as a drug nanocarrier for administration of nutrients and therapeutic drugs, such as liposome in mRNA or DNA vaccines. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Efpeglenatide is a long-acting agonist of the glucagon-like peptide (GLP-1) receptor. efpeglenatide improves insulin sensitivity and slows weight loss in mice models of diabetes and obesity. efpeglenatide has been used in studies of type II diabetes.

Emapticap pegol is a pro-inflammatory chemokine C-C motif ligand 2 (CCL2) inhibitor. emapticap pegol is also a 40-nucleotide oligonucleotide aptamer that exhibits different forms of Spiegelmers (L-RNA aptamers) in human (NOX-E36) and mouse (mNOX-E36).

Aminooxy-PEG4-alcohol is both a non-cleavable 4-unit PEG ADC linker and a PEG-based PROTAC linker.

DSPE-PEG-DBCO, MW 3,400 is a PEG lipid conjugate featuring a DSPE phospholipid and a DBCO group. DSPE is a saturated phospholipid that is commonly used to prepare lipid nanoparticles in drug delivery, while DBCO is a click chemistry handle that is frequently used to conjugate with azides on target molecules to form stable triazole linkages.

DBCO-PEG4-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound. Reagent grade, for research purpose.

NH-bis(PEG8-azide) is a bifunctional linker with two azides joined together by a secondary amine. The azides are useful for click chemistry with terminal alkynes or strained cyclooctynes while the amine can be used in reactions with carboxylic acids, ketones and aldehydes.

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