PEG

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N-(t-butyl ester-PEG6)-N-bis(PEG6-amine) is a trifunctional PEG linker containing two primary amines and a t-butyl ester. The amines are most often used in coupling reactions with activated esters or carboxylic acids, while the t-butyl ester can be deprotected for reaction with amines or other nucleophiles.

N-(acid-PEG6)-N-bis(PEG6-amine), HCl salt is a trifunctional PEG linker with two amines and one carboxylic acid, joined together by a tertiary amine. The amines are free for use as nucleophiles, while the carboxylic acid is free for coupling or esterification reactions as well.

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t-Boc-N-amido-Tri-(azide-PEG23-ethoxymethyl)-methane is a large PEG linker with three azides and a primary amine that is Boc-protected. The azide groups are open for click chemistry with terminal alkynes or strained cyclooctynes, while the Boc may be deprotected to allow for coupling reactions with carboxylic acids. Large PEG spacers and amide bonds along the chain provide high aqueous solubility with altered DMPK properties in vivo.

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m-PEG-NH2 HCl salt, MW 30,000 is a large PEG linker containing a methoxy cap and a primary amine. Primary amines are often applied in coupling reactions with carboxylic acids and activated esters in the presence of activators such as HATU or EDC. The amine in this compound is provided as an HCl salt, and therefore it needs to be deprotonated in basic conditions before use as a nucleophile. The use of PEG linkers is associated with higher aqueous solubility, which in turn impacts ADME in drug delivery.