PEG

Azido-PEG12-azide is a aqueous soluble, monodisperse PEG linker containing two azide groups.The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Reagent grade, for research use only.

mPEG-Cholesterol, MW 2,000 is a PEG derivative which self-assembles in water to form micelle-like structure. The cholesterol tail can be used to encapsulate hydrophobic drugs while the PEG chain ehances the water solubility of the micelles. Reagent grade, for research use only.

DBCO-PEG-amine TFA salt, MW 2,000 is a polyPEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound. Reagent grade, for research use only.

Thiol-PEG-DMG, MW 2,000 has a terminal thiol group and is used for liposome preparation. The terminal thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. Thiol-PEG-DMG can be used in the research on lipid nanoparticle (LNP) preparation. Reagent grade, for research use only.

DBCO-C5-acid is an analog of DBCO-Acid with an extended 5-carbon atom spacer arm. The extended 6-carbon atom spacer arm improves its derivatization efficiency and the stability of the yielded conjugates. This spacer arm also improves solubility in organic solvents such as dichloromethane, chloroform, THF, and ethyl acetate. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only.

DBCO-C5-NHS ester is an amine-reactive compound, which can be used to modify an amine-containing molecule in organic media. This reagent isn't soluble in aqueous media. The extended 5-carbon atom spacer arm improves solubility in commonly used organic solvents including dichloromethane, chloroform, THF, and ethyl acetate and it also improves derivatization efficiency and stability of conjugates. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only.

t-Boc-N-amido-PEG8-NHS ester is a PEG linker containing an NHS ester and a Boc-protected amine group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The Boc group can be deprotected under mild acidic conditions to form a free amine. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Reagent grade, for research use only.

Bromo-PEG11-azide is a PEG linker containing a bromide group and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. Reagent grade, for research use only.

DBCO-PEG4-Butyraldehyde is a click chemistry PEG reagent containing a terminal butylraldehyde group. Butyraldehyde reacts with hydrazide to form a stable hydrazone linkage or with alkoxyamines to form a stable oxime bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only.