PEG

Azido-PEG8-Amido-Val-Cit-PAB-PNP is a cleavable peptide ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. PNP groupg is a good leaving group when treating with aminebearing payload. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry, PEG spacer increases aqueous solubility. Reagent grade, for research purpose.

mPEG-DPPE, 2,000 MW is composed of two fatty acids, a glycerol unit, a phosphate group and a poly PEG head. The phosphate group and polar head region of the molecule is hydrophillic, while the fatty acid tail is hydrophobic. mPEG-DPPE, 2,000 MW can be used for lipid nanoparticle (LNP) preparation for siRNA (small interfering RNA) delivery research. Reagent grade, for research purpose.

bis-succinimidyl carbonate-PEG, MW 2,000 is a poly PEG linker that contains two terminal succinimdyl carbonate moieties. The succinimidyl carbonate group is a good leaving group and commonly reacts with amine nucleophiles. The hydrophilic PEG linker increases the water solubility of the compound. Reagent grade, for research purpose.

Azido-PEG4-Val-Cit-PAB-PNP is a cleavable peptide ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. PNP groupg is a good leaving group when treating with aminebearing payload. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry, PEG spacer increases aqueous solubility. Reagent grade, for research purpose.

Azido-PEG8-Amido-Val-Cit-PAB is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry, PEG spacer increases aqueous solubility. Reagent grade, for research purpose.

DBCO-PEG-NHS ester, 3,400 MW is a click chemistry poly PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research purpose.

Azide-PEG5-c18-t-butyl ester is a PEG linker with a steric acid tail and a terminal azide group. Stearic Acid is a saturated long-chain fatty acid with an 18-carbon backbone. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry. The PEG spacer increases aqueous solubility. Reagent grade, for research purpose.

DBCO-PEG-NHS ester, MW 5,000 is a click chemistry poly PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research purpose.

4-Arm PEG5-Amine is a multiarm PEG linker containing four terminal amines which can be reacted with NHS ester in an aqueous solution at pH 7 to 9. Reagent grade, for research purpose.