PEG

DSPE-PEG-endo-BCN, MW 5,000 is a phospholipid PEG polymer which can be used to encapsulate drugs/therapeutics agents in targeted drug delivery system, such as liposome based mRNA vaccine. The BCN group enable copper free click chemitry with azide-tagged molecules. Reagent grade, for research purpose.

DBCO-PEG-NHS ester, MW 1,000 is an azide reactive PEGylation reagent. DBCO reacts with azide (N3) efficiently without the presence of Cu catalyst known to be highly toxic for cells. The NHS-ester is reactive with amine at pH 6.5 to 7.5 to form a stable amide bond. Reagent grade, for research purpose.

Iodoacetamido-PEG3-t-butyl ester is a PEG reagent containing an Iodoacetamide group and a t-butyl ester. The iodoacetamide group is an alkylating agent that can be used to bind covalently with the thiol group. The t-butyl ester groups can be deprotected under acidic conditions. Reagent grade, for research purpose.

DBCO-PEG12-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound. Reagent grade, for research purpose.

18-(Azide-PEG3-ethylcarbamoyl)heptadecanoic-t-butyl ester is a PEG linker with an azide group and an alkane tail that has a terminal t-butyl ester group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The polymer can form micelles spontaneously in water. It may also be used to prepare more complex lipids for nanoparticles for drug delivery. Reagent grade, for research purpose.

14-(Azide-PEG4-ethylcarbamoyl)tridecanoic-t-butyl ester has an azide group on a PEG linker with a alkane tail that has a t-butyl ester group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. 14-(Azide-PEG4-ethylcarbamoyl)tridecanoic-t-butyl ester is a self-assembling PEG reagent which may form micelles in water. This compound may also be used as a building block for lipids in nanotechnolgy and drug delivery. Reagent grade, for research purpose.

N-(Propargyl-PEG2)-DBCO-PEG3-N-Boc enables formation of triazole linkage with azide-bearing compound via copper catalyzed Click Chemistry. Under mild acidic conditions, t-Boc group can be removed to yield the free amine. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry. Reagent grade, for research purpose.

16-(Azide-PEG5-ethylcarbamoyl)pentadecanoic-t-butyl ester is a PEG linker with an azide group and an alkane tail that has a terminal t-butyl ester group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The polymer can form micelles spontaneously in water. It may also be used to prepare more complex lipids for nanoparticles for drug delivery. Reagent grade, for research purpose.

m-PEG-Vinylsulfone, MW 10,000 poly PEG with a terminal vinyl sulfone group. The vinyl sulfone is reactive with thiol molecule via thiol-ene reaction for bioconjugation. Reagent grade, for research purpose.