PEG

DSPE-PEG-TCO, MW 2,000 is a large PEG-lipid with a DSPE group and a trans-cyclooctyne moiety. DSPE is a phospholipid known for spontaneously forming micelles in aqueous media. DSPE-PEG conjugates are commonly used in the development of lipid nanoparticles in drug delivery. TCO is a click chemistry handle that is used with tetrazine-containing compounds for highly efficient labeling.

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PEG3-bis(Amino-Tri-(Propargyl-PEG8-ethoxymethyl)-methane) is large molecule with two sets of three terminal alkynes joined together by a short PEG linker. The alkynes are most frequently used in copper click chemistry with azides to form stable triazoles with the target compound. The PEG linkers as well as numerous amide bonds provide high aqueous solubility to this compound, which may alter DMPK of this compound.

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14-(Bromoacetamido-PEG6-ethylcarbamoyl)tridecanoic t-butyl ester is a bifunctional PEG linker containing a bromoacetamide, a PEG6 spacer, and a tridecanoic t-butyl ester. Bromoacetamide is a thiol-specific covalent ligand while the t-butyl ester can be hydrolyzed to allow for reactions with amines or alcohols to form amides or esters respectively.

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