PEG

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NH-bis(PEG8-t-butyl ester) is a bifunctional PEG linker with a pair of t-butyl esters joined together at a secondary amine. The secondary amine can be used as a nucleophile while the t-butyl esters can be deprotected to allow for reactions with nucleophiles such as amines or alcohols. The use of a PEG spacer increases aqueous solubility and will impact the ADME of the final PEG conjugate.

N-(NHS ester-PEG6)-N-bis(PEG6-N-Boc) is a trifunctional PEG linker that combines an activated NHS ester and two Boc-protected amines ligated together at a tertiary amine. The NHS ester is highly reactive towards nucleophiles like amines while the Boc protected amine can be deprotected and used in coupling reactions with carboxylic acids or activated esters.

DOPE-PEG-DBCO, MW 2,000 is a PEG-lipid containing a DOPE and a DBCO group. DOPE is a phospholipid that is commonly employed in the development of lipid nanoparticles. DBCO is a click chemistry handle which is used to react with azides and form stable triazoles with target molecules.

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DSPE-PEG-BDP FL, MW 2,000 is a PEG lipid with a DSPE group and a BDP FL fluorophore. DSPE is a phospholipid that is used in the development of lipid nanoparticles in the field of drug delivery. BDP FL is a fluorescent dye with excitation and emission maxima at 504 nm and 514 nm respectively.

N-(t-butyl ester-PEG24)-N-bis(PEG23-Azide) is a trifunctional molecule combining two azides and a t-butyl ester, all joined together by a tertiary amine at its center. The azide functions can be used in click chemistry with terminal alkynes or strained cyclooctynes like BCN or DBCO while the t-butyl ester can be deprotected and made into amides or esters by reacting with amines or alcohols respectively. The PEG spacer provides aqueous solubility and altered DMPK.

Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V