PEG

0

DOPE-PEG-FITC, MW 5,000 is a PEG-lipid that features a DOPE phospholipid and an FITC fluorophore. DOPE is an unsaturated phospholipid that is commonly used to prepare lipid nanoparticles in drug delivery, while FITC is a green fluorophore with excitation and emission maxima at 491 nm and 516 nm respectively. FITC-PEG conjugates see frequent use in fluorescence microscopy, immunohistochemistry and other in vivo research applications.

N-(Acid-PEG8)-N-bis(PEG8-Azide) is a trifunctional molecule that combines two azide functions with a carboxylic acid via a tertiary amine at its center. The azides can be reacted with terminal alkynes or cyclooctynes to form stable triazoles with a target molecule. Meanwhile, the carboxylic acid can be coupled with amines using reagents such as HATU or EDC.

0

DSPE-PEG-DBCO, MW 2,000 is a PEG lipid conjugate featuring a DSPE phospholipid and a DBCO group. DSPE is a saturated phospholipid that is commonly used to prepare lipid nanoparticles in drug delivery, while DBCO is a click chemistry handle that is frequently used to conjugate with azides on target molecules to form stable triazole linkages.

DSPE-PEG-DBCO, MW 5,000 is a PEG lipid conjugate featuring a DSPE phospholipid and a DBCO group. DSPE is a saturated phospholipid that is commonly used to prepare lipid nanoparticles in drug delivery, while DBCO is a click chemistry handle that is frequently used to conjugate with azides on target molecules to form stable triazole linkages.

DOPE-PEG-Cy5, MW 2,000 is a PEG lipid consisting of a Cy5 dye and a DOPE phospholipid. DOPE is featured prominently in the development of lipid nanoparticles while Cy5 is a bright red fluorescent dye with excitation and emission maxima at 651 nm and 670 nm respectively.

N-Boc-N-bis(PEG8-NHS ester) is a trifunctional linker containing two NHS esters and a Boc-protected secondary amine. The NHS esters are highly activated towards amines while the secondary Boc-amine can be deprotected and itself used as a nucleophile.

N-(NHS ester-PEG8)-N-bis(PEG8-azide) is a trifunctional PEG linker that combines two azides with an activated NHS ester. The NHS ester is highly activated for reaction to form amides. The azides are most often used for click chemistry with terminal alkynes, BCN, and DBCO functional groups. Finally, PEG spacers provide high aqueous solubility.