PEG

DOPE-PEG-Cy5, MW 5,000 is a PEG lipid consisting of a Cy5 dye and a DOPE phospholipid. DOPE is featured prominently in the development of lipid nanoparticles while Cy5 is a bright red fluorescent dye with excitation and emission maxima at 651 nm and 670 nm respectively.

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N-Boc-N-bis(PEG8-acid) is a bifunctional PEG linker with two carboxylic acids and an N-Boc protected secondary amine. The carboxylic acids are most frequently used to couple with alcohols and amines while the Boc-amine can be deprotected in acid and applied as a nucleophile to form a trifunctional molecule.

Azide-PEG8-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a multifunctional reagent containing an azide and three t-butyl esters. The azide is reactive with terminal alkynes, DBCO, BCN for click chemistry. The t-butyl esters can be deprotected and subsequently reacted with primary amine groups to form stable amide bonds.

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DSPE-PEG-Fluor 555, MW 2,000 is a PEG lipid conjugate with a DSPE group and a Fluor 555 dye. Fluor 555 is a bright orange cyanine-based dye while DSPE is a phospholipid frequently employed in the development of lipid nanoparticles.

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