PEG

N-(Azide-PEG8)-N-bis(PEG8-NH-Boc) is a trifunctional chemical reagent with two Boc-protected amines and one azide. The azide is often applied in click chemistry to react with terminal alkynes or strained cyclooctynes like DBCO and BCN. The Boc protecting groups can be removed to allow for the primary amines to react with carboxylic acids in the presence of activators (ex. EDC, HATU) to form amides.

DOPE-PEG-Fluor 488, MW 2,000 is a PEG lipid featuring a DOPE phospholipid and a Fluor 488 dye. DOPE is a phospholipid that is known to spontaneously form micelles in water and is featured heavily in lipid nanoparticles and drug development, while Fluor 488 is a cyanine dye that is prominently used in fluorescence microscopy. Fluor 488 has excitation and emission maxima at 499 nm and 520 nm.

N-(Azide-PEG8)-N-bis(PEG8-Amine) is a trifunctional PEG reagent containing two primary amines and one azide. The primary amine is reactive with carboxylic acids, NHS esters, or carbonyls to form a variety of stable bonds. The azide can be used to do click chemistry with terminal alkynes or strained cyclooctynes like DBCO or BCN.

Mal-Amide-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker featuring a maleimide, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB functional group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads, while the maleimide is used to covalently bind free thiols on the cysteine residues of proteins. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.

DOPE-PEG-Fluor 488, MW 5,000 is a PEG lipid featuring a DOPE phospholipid and a Fluor 488 dye. DOPE is a phospholipid that is known to spontaneously form micelles in water and is featured heavily in lipid nanoparticles and drug development, while Fluor 488 is a cyanine dye that is prominently used in fluorescence microscopy. Fluor 488 has excitation and emission maxima at 499 nm and 520 nm.

FITC-PEG-Acid, MW 3,400 is a chemical reagent featuring an FITC fluorophore and a carboxylic acid. FITC is a green fluorophore with excitation and emission maxima at 491 nm and 516 nm respectively. FITC-PEG conjugates see frequent use in fluorescence microscopy, immunohistochemistry and other in vivo research applications. Carboxylic acids are easily reactive towards amines and alcohols to form amides or esters respectively.

Benzyl-PEG-OH, MW 2,000 is a PEG reagent featuring a primary alcohol and a benzyl-protecting group. The alcohol is a versatile scaffold and can be manipulated in a variety of ways such as in creating esters or substituting with electrophiles such as halogens, mesylates, triflates, etc. The benzyl protecting group can be removed by hydrogenation to reveal a second alcohol group for further reactions.

N-(Boc-PEG4)-N-bis(PEG4-propargyl) is a trifunctional chemical containing two terminal alkynes and a Boc-protected primary amine. The terminal alkynes are used in copper click chemistry with azides to form stable triazole linkages with the target molecule while the carboxylic acids are reactive towards alcohols and primary amines to form esters and amides respectively.