Results for PEG ( 6387 )
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N-(Mal-PEG8-carbonyl)-N-bis(PEG8-t-butyl ester) is a trifunctional PEG linker containing two t-butyl esters and a maleimide joined together at a tertiary amide. Maleimide is a thiol-specific covalent ligand, often used for labeling cysteine residues along proteins. The two t-butyl esters can be deprotected to allow for reaction with amines or alcohols to form amides and esters respectively. The tertiary amide increases aqueous solubility through hydrogen bonding effects.
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DSPE-PEG-Mannose, MW 2,000 is a PEG lipid that features a DSPE phospholipid and a mannose sugar residue. DSPE is a phospholipid featured prominently in lipid nanoparticles for its ability to readily form micelles while mannose is a sugar which can be used to bind receptors featured prominently on tumor cells.
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N-(Azide-PEG8-carbonyl)-N-bis(PEG8-NHS ester) is a trifunctional reagent that combines an azide and two NHS esters with a tertiary amide junction. The activated NHS ester is reactive towards nucleophiles like amines and alcohols to form amides and esters while the azide is useful for click reactions with terminal alkynes and strained cyclooctynes like DBCO and BCN. The tertiary amide that links the two increases the molecule’s water solubility through hydrogen bonding effects.
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N-(Mal-PEG4-carbonyl)-N-bis(PEG4-NHS ester) is a trifunctional linker that combines maleimide with two activated NHS esters. NHS esters are highly activated towards reactions with amines and alcohols to form amides and esters respectively, while Maleimide is a thiol-specific covalent ligand that is capable of easily labeling proteins such as antibodies. The central junction of this molecule is an amide, allowing for hydrogen bonding to increase the water solubility of this compound.