PEG

Amino-PEG8-amine is a pegylated based PROTAC linker that can be used in the synthesis of PROTACs. It is a conjugate PEG derivative containing two amino (NH2) groups.

Azide-PEG3-Desthiobiotin is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

Benzyloxy carbonyl-PEG4-acid is a linker with a benzyl protecting group and a carboxylic acid. The carboxylic acid can undergo reactions with primary amines with the help of activators (EDC or HATU). The benzyl protecting group can be removed via hydrogenolysis.

Biotin-PEG3-NHS ester is a PROTAC linker based on the PEG structure that facilitates the preparation of PROTAC.

m-PEG12-amine is a PEG-based PROTAC linker and a non-cleavable 12-unit PEG ADC linker used in the synthesis of PROTACs [1] and antibody-drug conjugates (ADCs) [2].

NH-bis(PEG3-azide) is a PROTAC linker of the PEG class used in the synthesis of PROTAC molecules.

PC Biotin-PEG3-alkyne is an ADC linker, cleavable 3-unit PEG, which can also be used to synthesize antibody drug conjugates (ADCs).

TCO-PEG4-NHS ester is a PROTAC linker bridge in the PEG class, used for synthesizing various PROTAC molecules. As a cleavable and synthetic ADC, it is also utilized in the synthesis of antibody-drug conjugates (ADCs).

DBCO-mPEG (MW 5kDa) is a PEG-based linker utilized in PROTACs to connect two essential ligands, facilitating selective protein degradation through the ubiquitin-proteasome system.