PEG

m-PEG-Vinylsulfone, MW 5,000 is a large PEG linker with a methoxy cap and a vinylsulfone residue. The vinylsulfone group is a thiol-specific covalent ligand which is used for labeling proteins via the amino acid, cysteine. The methoxy cap is a relatively inert structure which allows PEGylation to selectively proceed on the vinylsulfone.

m-PEG-Vinylsulfone, MW 20,000 is a large PEG linker with a methoxy cap and a vinylsulfone residue. The vinylsulfone group is a thiol-specific covalent ligand which is used for labeling proteins via the amino acid, cysteine. The methoxy cap is a relatively inert structure which allows PEGylation to selectively proceed on the vinylsulfone.

bis-Vinylsulfone-PEG, MW 5,000 is a large PEG reagent featuring two vinylsulfone groups. Vinylsulfone is a cysteine-specific covalent linker that is used to label proteins. PEG crosslinking is well-known to increase the aqueous solubility of the final conjugate and alter ADME.

m-PEG-Glu-Glutamic acid, MW 20,000 is a large PEG linker with a methoxy cap and a bis(glutamic acid) dipeptide. The methoxy cap is relatively inert, allowing any reactivity to occur at the glutamic acid residues. The glutamic acid dipeptide features three carboxylic acids which can be used to build larger conjugates via amide or ester bonds.

PLA(2.5k)-mPEG(5k) is a PEG-PLA copolymer featuring a methoxy cap. Poly(D, L lactide) is a hydrophobic polymer which, when combined with the hydrophilic PEG, is capable of self-assembling into micelles in aqueous media. This copolymer can be used to prepare nanoparticles for use in drug delivery.

m-PEG-Phosphate, MW 5,000 is a PEG linker containing a methoxy cap and a terminal phosphate group. Phosphates can be used to link with alcohols to form phosphodiester bonds such as those found in nucleic acids and phospholipids.

m-PEG-Iodoacetamido, MW 5,000 is a PEG linker featuring a methoxy cap and an iodoacetamide group. Iodoacetamide is a covalent ligand used in binding thiols such as those featured in the amino acid cysteine. The methoxy cap is fairly inert, allowing conjugation to selectively occur at the iodoacecetamide.

m-PEG-Propionic acid, MW 5,000 is a PEG linker with a methoxy cap and a carboxylic acid. The carboxylic acid is readily used to create amides and esters with amines or alcohols, while the methoxy cap is unreactive and allows PEGylation to selectively proceed at the carboxylic acid.

m-PEG-Hexanoic acid, MW 5,000 is a PEG linker with a methoxy cap and a carboxylic acid. The carboxylic acid is readily used to create amides and esters with amines or alcohols, while the methoxy cap is unreactive and allows PEGylation to selectively proceed at the carboxylic acid.