PEG

0

N-(Mal-PEG4-carbonyl)-N-bis(PEG4-acid) is a bifunctional reagent with two carboxylic acids and a maleimide group. Maleimide is a thiol-specific covalent ligand that is often used in labeling proteins, while the carboxylic acids are open for reaction with primary amines to form amide bonds. PEG linkers are highly water soluble but the inclusion of an amide bond makes this molecule especially so.

0

N-(azide-PEG10)-N-(PEG10-N-boc)-N-(PEG10-t-butyl ester) is a trifunctional PEG linker with an azide, a Boc-protected amine, and a t-butyl ester. The azide can be used in click chemistry with terminal alkynes and strained cyclooctynes like DBCO or BCN. t-Butyl esters can be deprotected using acidic or basic conditions to allow for amide coupling or esterification. Finally the Boc-protecting group can be removed with acid, allowing the primary amine to engage in reactions with carboxylic acids, aldehydes or ketones to form stable bonds with other molecules.

0

3-(PEG4-Azide)-2-((PEG4-Azide)methyl)propan-1-ol is a trifunctional linker with two azides and a primary alcohol group. The azides are applied in click chemistry with terminal alkynes and strained cyclooctynes like DBCO and BCN while the alcohol can be used in numerous ways such as forming esters with carboxylic acids. The use of a PEG linker provides this molecule with aqueous solubility.

3-Arm PEG4-Azide is a homotrifunctional PEG linker containing three azides, which can be used in click chemistry with terminal alkynes and strained cyclooctynes like DBCO and BCN. The use of PEG linkers over their alkane counterparts provides high aqueous solubility and alters in vivo pharmacodynamics.

DOPE-PEG-Cy5.5, MW 2,000 is a PEG-lipid-dye conjugate featuring a DOPE phospholipid and a Cy5.5 dye. DOPE is featured prominently in lipid nanoparticles for its ability to readily form micelles while Cy5.5 is a fluorescent dye which is used in histology, FRET and other fluorescence-based assays in vivo.

0