PEG

ZXH 3-26 degrades BRD4 while not exhibiting any significant degradation of BRD2 or BRD3. This product is ready for conjugation to target proteins for PROTAC R&D. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

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N-(Amino-PEG4)-N-bis(PEG4-Azide) is a three-armed PEG linker containing two azide groups and a primary amine. The two azides are free for click chemistry with terminal alkynes or strained cyclooctynes such as DBCO or BCN while the primary amine is reactive towards carboxylic acids and other carbonyl-containing functional groups. The junction combining this molecule’s branches is a tertiary amine.

2-((2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)methyl)propane-1,3-diol is a small trifunctional compound which contains an azide as well as two primary alcohols. Azides are commonly applied for click chemistry with terminal alkynes, BCN, or DBCO while alcohol groups are versatile building blocks for building larger compounds. The use of a PEG linker increases this compound’s aqueous solubility, altering its DMPK properties in drug development.

3,4-(PEG4-Azide)-2-((PEG4-Azide)methyl)propan-1-ol is a multifunctional reagent combining three azides and a primary alcohol. The azide group is commonly used in click chemistry for reactions with terminal alkynes as well as strained cyclooctynes such as BCN or DBCO. The primary alcohol is a useful scaffold for building molecular complexity such as for creating esters or substitution with any number of functional groups. The use of a PEG linker increases this compound’s aqueous solubility, altering its DMPK properties in drug development.

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