PEG

N-(Amine-PEG8)-N-bis(PEG8-Propargyl) is a trifunctional linker containing an amino group and two terminal alkynes. These alkynes are frequently used in copper (I) click reactions with azides to form stable triazole linkages, while the primary amine is reactive towards carboxylic acids and other carbonyl compounds such as NHS esters, aldehydes or ketones.

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DOPE-PEG-Fluor 555, MW 2,000 is a PEG-lipid-dye conjugate featuring a DOPE phospholipid and a Fluor 555 dye. DOPE is featured prominently in lipid nanoparticles for its ability to readily form micelles while Fluor 555 is a fluorescent dye which is used in histology, FRET and other fluorescence-based assays in vivo.

1-(PEG-Amine)-2,3-(PEG4-Azide) is a trifunctional linker containing two azides and a primary amine. This amine can be used to couple with carboxylic acids in the presence of an activator such as HATU or EDC, while the azides are open to do click chemistry with terminal alkynes or strained cyclooctynes. PEG linkers are highly water soluble and altering chain length will impact DMPK in drug discovery applications.

2,3,4-(PEG4-Azide)-1-(PEG4-Amine)methane is a four-armed PEG reagent that combines three azide groups with a primary amine. Azides are frequently used in click reactions with terminal alkynes, DBCO and BCN moieties to form stable triazole linkages with the target molecule. Primary amines are useful scaffolds for easily building complexity such as in making amides, building heterocycles, and performing SNAr reactions on electron-deficient aromatic compounds. PEG linkers increase a molecule’s water solubility and their use impacts a compound’s ADME properties in vivo.

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2,3,4-(PEG4-Azide)-1-(PEG4-N-Boc)methane is a multifunctional PEG linker containing three azides and a Boc-protected primary amine. Azides are commonly used reagents in click chemistry, easily reacting with terminal alkynes or strained cyclooctynes like BCN or DBCO to form stable triazole links with the target molecule. The primary amine can be used for coupling to carboxylic acids in the presence of an activator such as EDC or HATU to form amide bonds.