PEG

N-TETAMINE-pSar45 is a polysarcosine (pSar) derivative featuring an N-tetamine head group and a 45-mer polysarcosine tail. Sarcosine is an amino acid derivated that is being developed as an alternative to PEG for in vivo applications due to its biodegradability and highly reduced antigenicity. pSar-lipid derivatives such as this may be applied in the development of lipid nanoparticles.

N-TETAMINE-pSar35 is a polysarcosine (pSar) derivative featuring an N-tetamine head group and a 35-mer polysarcosine tail. Sarcosine is an amino acid derivative that is being developed as an alternative to PEG for in vivo applications due to its biodegradability and highly reduced antigenicity. pSar-lipid derivatives such as this may be applied in the development of lipid nanoparticles.

N-TETAMINE-pSar25 is a polysarcosine (pSar) derivative featuring an N-tetamine head group and a 25-mer polysarcosine tail. Sarcosine is an amino acid derivative that is being developed as an alternative to PEG for in vivo applications due to its biodegradability and highly reduced antigenicity. pSar-lipid derivatives such as this may be applied in the development of lipid nanoparticles.

N-TETAMINE-pSar45-Maleimide is a polysarcosine (pSar) derivative featuring an N-tetamine head group, a 25-mer polysarcosine tail, and a maleimide functional group. Sarcosine is an amino acid derivative that is being developed as an alternative to PEG for in vivo applications due to its biodegradability and highly reduced antigenicity. Maleimide is a strong Michael acceptor and is used to covalently bind thiols such as those found on cysteine residues in proteins. pSar-lipid derivatives such as this may be applied in the development of lipid nanoparticles.

N-TETAMINE-PEOZ-40 is a poly(2-ethyl-2-oxazoline) (PEOZ) derivative featuring an N-tetamine head group and a 40-mer polyoxazoline tail. Poly(ethyloxazoline) is a water-soluble polymer that is being researched for applications in drug delivery and materials science.

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N-Boc-N-bis(PEG4-Propargyl) is a bifunctional PEG compound containing two terminal alkynes that are combined together at a Boc-protected secondary amine. Terminal alkynes are most commonly used in copper click chemistry with azides to form stable triazoles with the target molecule. The secondary amine may be deprotected under acidic conditions to allow for alkylation at that position, increasing the molecule’s structural complexity. The use of a central amine also allows for hydrogen bonding, further increasing this compound’s water solubility.

NH-bis(PEG4-Propargyl) is a bifunctional PEG compound containing two terminal alkynes that are joined together at a secondary amine. Terminal alkynes are reactive towards azides in copper (I) click chemistry to form stable triazoles with the target compound. The secondary amine joining the two arms can be used as a nucleophile such as in alkylation via reductive amination or in forming amides with carboxylic acids or activated NHS esters. The use of a central amine also allows for hydrogen bonding, further increasing this compound’s water solubility.

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