PEG

m-PEG6-Tos is a PEG-based linker for PROTACs, facilitating the formation of PROTAC molecules by joining two essential ligands. This linker enables selective protein degradation through the [ubiquitin-proteasome system] within cells.

m-PEG8-Amine is a cleavable linker integral to ADC synthesis, joining cytotoxic drugs to antibodies to enable precise delivery to cells or proteins. Its cleavable nature ensures controlled drug release, thereby optimizing ADC effectiveness.

m-PEG8-Br is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Mal-amido-PEG2-TFP ester is a polyethylene glycol (PEG)-based linker featuring amide functionality and a trifluorophenyl (TFP) ester group, used in PROTAC synthesis as a PEG-based PROTAC linker [1].

Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable, 2-unit polyethylene glycol (PEG) based ADC linker used in the construction of antibody-drug conjugates (ADCs) [1].

Mal-Amido-PEG4-Boc is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-amido-PEG4-TFP ester, a PEG-based PROTAC linker, finds utility in the synthesis of PROTACs[1].

Mal-amido-PEG8-C2-acid (US2018339985, example 142) is a noncleavable linker for antibody-drug conjugates (ADCs) [1].

Mal-amido-PEG9-acid is a PEG-based linker for PROTACs, crucial for joining two essential ligands and facilitating selective protein degradation by leveraging the ubiquitin-proteasome system within cells.