Nucleotides

5-Fluoro-1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione has been shown to be a chemotherapeutic agent and is converted to 5-fluorouracil in the body, which inhibits cancer cell growth by inhibiting DNA synthesis and RNA synthesis. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

5-Bromo-2'-deoxyuridine is a nitrate reductase inhibitor that prevents the reduction of nitrate to nitrite by inhibiting the enzyme nitrate reductase. 5-Bromo-2'-deoxyuridine is a genotoxic agent that has been shown to cause DNA damage and cell death in vitro. 5-Bromo-2'-deoxyuridine also binds to NMDA receptors and may be useful as a model system for studying neurodegenerative diseases. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Tecadenoson is an analog of adenosine. Tecadenoson works by activating two types of receptors: A1 and A2A. Activation of these receptors leads to increased blood supply, which improves symptoms in patients with chronic obstructive pulmonary disease. Tecadenoson has also been shown to reduce inflammation and improve lung function in animal models of asthma. Tecadenoson is not active against bacterial infections or viral infections, but is effective against autoimmune diseases such as lupus erythematosus, rheumatoid arthritis, and vasculitis. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2',3'-Isopropylideneuridine has been shown to inhibit binding of pestivirus inhibitors by monoclonal antibodies. 2',3'-Isopropylideneuridine was also found to inhibit the replication of human immunodeficiency virus (HIV) in tissue culture by binding to the viral RNA polymerase and inhibiting its activity, preventing viral replication. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2-Aminoadenosine is a nucleoside analog that is used as a substrate for the enzyme adenosine deaminase. 2-Aminoadenosine inhibits the growth of certain cancer cells by inhibiting the activity of DNA polymerase and RNA polymerase. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-Deoxyadenosine monohydrate is an adenosine nucleotide, which can be synthesized by the enzyme adenosine kinase. 2'-Deoxyadenosine monohydrate is a competitive inhibitor of phosphodiesterase, which breaks down cyclic nucleotides to their corresponding monophosphate form. This leads to elevated levels of cAMP, which can cause neuronal death by apoptosis. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

4-Methylumbelliferyl-beta-D-glucuronide is a fluorescent substrate of β-glucuronidase. Once cleaved, 4-Methylumbelliferyl-beta-D-glucuronide yields blue fluorescence seen under UV light which is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively. It is ideal for working with Escherichia coli and plant molecular studies. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

5'-O-(tert-Butyldimethylsilyl)thymidine is a synthetic nucleoside that is used as an antiviral agent in the treatment of herpes zoster and other viral infections. 5'-O-tert-Butyldimethylsilyl-D3-thymidine is a novel monophosphate, which can be activated to a diphosphate by either kinases or phosphoramidites. It has been shown to be effective against herpes virus and other DNA viruses that infect cells from various species. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

8-Bromoadenosine is a nucleotide that is structurally related to adenosine. It can be used as an inhibitor of guanine nucleotide-binding proteins and has shown biological properties in vitro. 8-Bromoadenosine has been shown to inhibit the mitochondrial membrane potential, cytosolic Ca2+, and the synthesis of RNA and protein. 8-Bromoadenosine also inhibits leukemia inhibitory factor (LIF) production by 3T3-L1 preadipocytes and induces apoptosis in T84 cells. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.