Nucleotides

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Beta-Pseudouridine is an Uridine isomer and found in tRNA. Studies suggest that Beta-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Alpha-Pseudouridine is an isomer of Pseudouridine. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Beta-1-Methylpseudouridine is a substitute for uridine in modified mRNA and has been shown to increase transfection by reducing immuogenicity. Beta-1-Methylpseudouridine substituted mRNA increases protein expression due to low immune stimulation as it evades detection by the edosomal Toll-like receptor (TLR3). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2-Thiouridine is a uridine derivative that acts as a precursor for protein synthesis. 2-Thiouridine has been shown to reducing inflammation through immunomodulatory effects due to its ability to act as an inhibitor of fatty acid synthase, which generates fatty acids from acetyl CoA. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-O-Methyladenosine is a nucleoside that is a low-energy analog of adenosine. 2'-O-Methyladenosine has been shown to inhibit RNA polymerase in the process of transcription, which effectively inhibits protein synthesis in vitro. 2'-O-Methyladenosine has also been shown to inhibit virus replication in vitro by binding to the viral ribonucleotide reductase enzyme and blocking the conversion of ribonucleotides into deoxyribonucleotides. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-O-Methylcytidine is a nucleoside with a hydroxyl group on the 2' carbon, which makes it an effective inhibitor of viral replication. 2'-O-Methylcytidine is also metabolized by nucleotide salvage pathways and may be able to bind to the response element on DNA, which could inhibit protein synthesis in cancer cells. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-O-Methylguanosine is a nucleoside that contains a 2'-O-methyl group at the 2' position of the ribose. 2'-O-Methylguanosine has been shown to be an inhibitor of DNA polymerase and an activator of RNA polymerase, as well as present in relatively high concentrations in tissues, such as liver and muscle, where it is involved in metabolism or energy production. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

3'-O-Methyladenosine is a monomethylated adenosine. 3'-O-Methyladenosine may help the regulation of blood pressure and central nervous system function by inhibitiong the activity of adenosine receptors. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.