Nucleotides

2'-Deoxy-L-guanosine is a nucleoside that shows antibiotic properties by inhibiting protein synthesis, leading to cell death. This is done by binding to the ribose phosphate backbone of DNA, phosphorylating it, and preventing the base pairing of adenosine with thymine. 2'-Deoxy-L-guanosine shows a high level of resistance against bacteria and is effective in the treatment of gram-positive bacteria. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond. Adenosine works in the energy transfer-as adenosine triphosphate (ATP) and adenosine diphosphate (ADP)-as well as in signal transduction as cyclic adenosine monophosphate, cAMP. It shows neuromodulatory, cytoprotective, anti-inflammatory and cardioprotective actions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N2-Isobutyrylguanosine is a synthetic nucleoside analog. N-Isobutyrylguanosine can be used in the syntehsis of 2'-O-(o-nitrobenzyl)-3'-thioguanosine phosphoramidite which is then used to form oligonucleotides, substrates for probing the mechanism of RNA catalysis. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N4-Methylcytidine is a nucleoside analogue that inhibits synthesis of human mitochondrial DNA by inhibiting bacterial enzyme uridine-cytidine kinase, which converts uridine to cytidine in the mitochondria. N4-Methylcytidine has been shown to be potent against viruses such as HIV and herpes simplex virus type 1 (HSV-1) in cell culture studies. This antiviral effect is due to the interference with viral dna replication and protein synthesis by preventing incorporation of uracil into dna and ribosomal RNA. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N4-Acetylcytidine is a nucleotide-derived metabolite used as biomarkers for diagnosis of inflammation-related diseases. N4-Acetylcytidine is also a partially protected cytidine and therefore can be used as a synthetic building block to prepare further derivatized nucleosides such as 2’,3’-dideoxycytidine. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N6-(3-Methyl-2-butenyl)adenosine is a cytokinin growth regulator, a plant hormone, which can be produced endogenously by plants to direct differentiation of callus cells. N6-Isopentenyladenosine also has antiproliferative activity on MCF-7 breast cancer cells. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

5-Methoxyuridine is an intermediate in the biosynthesis of pyrimidines and is also used as a precursor for other compounds. 5-Methoxyuridine is an analog of Uridine and is used as a reagent in the synthesis of 5-OMe-UDP, a potent and selective P2Y6-receptor agonist. 5-Methoxyuridine inhibits messenger RNA (mRNA) production in bacteria by interfering with sequence recognition and binding sites within the ribosome and preventing. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-Deoxyadenosine-5'-monophosphate disodium salt is a nucleic acid AMP derivative found in DNA. 2′-Deoxyadenosine 5′-monophosphate disodium can be used to study adenosine-based interactions during DNA synthesis and DNA damage. 2'-Deoxyadenosine-5'-monophosphate disodium salt reacts with chloride ions to form 2',3'-diacetylpyridine-5'-diphosphate dibasic chloride, which has been shown to inhibit bacterial growth and act as an antibacterial agent. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Crotonoside is a purine analogue that is structurally similar to pyrazole, which also inhibits the polymerase chain reaction in vitro. Crotonoside has been shown to be an inhibitor of the polymerase chain reaction in vitro, but it is unclear if this activity will translate to in vivo models. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.