Nucleotides

2'-O-(2-Methoxyethyl)-guanosine is a guanosine derivative isolated from the reaction of 2-aminoadenosine with methylsulfonyl chloride. 2'-O-(2-Methoxyethyl)-guanosine can be used as a building block for cross-linking oligonucleotides. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Cytidine is a nucleoside that belongs to the group of pyrimidine nucleosides. Cytidine has also been shown to inhibit polymerase chain reactions (PCR) and enzyme activities, such as cytidine deaminase, which converts cytidine into uracil. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Regadenoson is an adenosine-A2A receptor agonist. The adenosine A2A receptor is a G-protein-coupled receptor and a key therapeutic target for oncologic, inflammatory, Parkinson's and cardiovascular diseases. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N,N-Dimethylguanosine is a purine nucleoside that is found in human serum and belongs to the group of purines and has been shown to be involved in energy metabolism. N2,N2-Dimethylguanosine has been shown to be present at high levels in patients with autoimmune diseases such as rheumatoid arthritis. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Dideoxycytidine is an anti-viral and works as a reverse transcriptase inhibitor. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2-Iodoadenosine is a chemical compound that is produced from the oxidation of uridine. It is used in the synthesis of peptides, which are important for biological processes like signal transduction and cell growth. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Nelzarabine is a drug that prevents the growth of cells by inhibiting the bcr-abl kinase, which is an intracellular target. This drug has been shown to be effective against pediatric patients with t-cell acute lymphoblastic leukemia and adults with chronic myeloid leukemia. Nelarabine has minimal toxicity in humans and is not toxic to healthy cells. It has been shown to have anti-inflammatory properties and may be used as a biomarker for autoimmune diseases. Nelarabine also inhibits angiogenesis, which may be due to its effects on nuclear DNA. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

5-Methyl-2'-deoxycytidine is a nucleoside analogue that inhibits the synthesis of DNA. 5-Methyl-2'-deoxycytidine prevents methylation of guanine, which disrupts the binding of guanine nucleotide-binding proteins to the dna template and prevents polymerase chain reactions. 2'-Deoxy-5-methylcytidine is also a methyltransferase inhibitor, which means it blocks the enzyme responsible for adding methyl groups to cytosine molecules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

3'-O-[tert-Butyl(dimethyl)silyl]thymidine is a nucleoside analog that is chemically stable and has been shown to be a potential biomarker for the diagnosis of fetal bovine spongiform encephalopathy (BSE). 3’-O-t-Bulyldimethylsilyl thymidine binds to basic proteins in the cell nucleus and has been shown to inhibit protein synthesis in tubule cells of the kidney and skin cancer cells. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.