Nucleotides

5-Fluoro-5’-deoxyuridine is a metabolite of the chemotherapeutic agent Capecitabine. 5-Fluoro-5’-deoxyuridine is an antimetabolite that inhibits the synthesis of DNA, RNA, and proteins by reversibly inhibiting ribonucleotide reductase. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Adenosine 5'-monophosphate disodium salt is a modified phosphoramidite used for the synthesis of deoxyribonucleosides and nucleosides. Adenosine 5'-monophosphate disodium salt is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). It may be used as a substrate by a variety of enzymes such as AMP-thymidine kinase, AMP deaminase and 5′-nucleotidase. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine is present in the cerebrospinal fluid, intestinal cells, blood-brain barrier and in brain microvessels. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-C-Methylcytidine is nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks viral production of HCV RNA and thus viral replication. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N6-Methyladenosine is a modified form of adenosine that contains a methyl group at the N6 position and has a high importance in epigenetics. The result of this modification is specifically recognized mRNA in the cytoplasm which regulates mRNA stability. N6-Methyladenosine is made when a protein complex containin the writer enzyme METTL3 adds a methyl group to adenosine. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Trifluridine is an inhibitor of thymidine phosphorylase. TFT also inhibits thymidylate synthase (TS), a rate-limiting enzyme of DNA biosynthesis, and is incorporated into DNA. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-Deoxyuridine is an intermediate in the synthesis of thymidylate, which is a precursor for DNA synthesis. 2'-Deoxyuridine has been shown to inhibit the enzymatic activity of enzymes responsible for synthesizing uridine and thymidylate, leading to neuronal death. 2'-Deoxyuridine has been used as a fluorescence probe for nucleic acids and as a polymerase chain reaction (PCR) substrate. 2'-Deoxyuridine is also known to bind with toll-like receptor 4 (TLR4), which is involved in inflammatory responses. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-Deoxy-5-fluorocytidine is a methyltransferase inhibitor that inhibits the activity of DNA methyltransferases. 2'-Deoxy-5-fluorocytidine has been shown to inhibit the activity of DNA methyltransferases and also target histones and ribosomes, leading to tumor cell death. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-O-Methyluridine is an analog of uridine and has been shown to have antiviral and anticancer properties. 2'-O-Methyluridine inhibits protein synthesis by competing with uridine for the active site of the enzyme ribonucleotide reductase, which converts ribonucleotides to dNMPs. This compound also inhibits RNA synthesis by disrupting the pairing of adenine and cytosine residues in RNA strands. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.