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Biotin-C4-amide-C5-NH2 is a linker containing a biotin group and a primary amine. Biotin is useful for affinity-based applications such as pull-down assays or for ligating with streptavidin proteins while the primary amine is versatile and can be used in coupling with carboxylic acids, reductive amination with aldehydes or ketones, or SNAr with electron-deficient aromatic groups.