Cell Line

Motor Neurons from ALS iPSCs. Express HB9, ISL1, ChAT. Functional with spontaneous activity. Ideal for ALS research.

Motor Neurons with TDP-43 Q331K mutation (HET). Useful for ALS and neurodegenerative disease studies.

Motor Neurons with TDP-43 Q331K mutation (HET). Useful for ALS and neurodegenerative disease studies.

Human Motor Neurons (iPSC-derived, TDP43 mutation, Q331K, HOM)

Human Motor Neurons (iPSC-derived, TDP43 mutation, Q331K, HOM)

Please note this product may be subject to fees, we invite you to contact your local office. ADAR1 Responsive Luciferase Reporter HEK293 Cell Line is a HEK293 cell line designed to respond to ADAR1 enzymatic activity. These cells were engineered to express an ADAR1 reporter construct comprised of an ADAR1 hairpin target with a stop codon (UAG) susceptible to ADAR1-mediated editing to tryptophan (UUG), located upstream of a firefly luciferase reporter. This cell line has been validated by comparing reporter activation after transfection with ADAR1 and ADAR2. This cell line has been used for the development of the constitutive ADAR1 expressing ADAR1 Activity Luciferase Reporter HEK293 Cell Line (#82239). The ADAR1 reporter construct is compromised of an ADAR1 hairpin targer with a stop codon (UAG) upstream of the sequence encoding luciferase. In the presence of ADAR1 activity, as in the case of transfection with ADAR1, adenine is converted into inosine encoding now the amino acid tryptop

Please note this product may be subject to fees, we invite you to contact your local office. ADAR1 Activity Luciferase Reporter HEK293 Cell Line is a HEK293 cell line designed to monitor the activity of ADAR1 (adenosine deaminase acting on RNA) enzyme. These cells were engineered to express ADAR1 (NM_001111.5) and an ADAR1 reporter construct comprised of an ADAR1 hairpin target with a stop codon (UAG) susceptible to ADAR1-mediated editing to tryptophan (UUG), located upstream of a firefly luciferase reporter. This cell line has been validated by comparing reporter activation to ADAR1 Responsive Luciferase Reporter HEK293 Cell Line (#82238) and in response to treatment with ADAR1 siRNA. The ADAR1 reporter construct is comprised of an ADAR1 hairpin target with a stop codon (UAG) upstream of the sequence encoding luciferase. In the absence of ADAR1, luciferase is not transcribed, and the cells show no luciferase activity. In the presence of ADAR1 activity, adenine is converted into inosin

CRISPR-Ready ioGlutamatergic Neurons

CRISPR-Ready ioMicroglia